All GLG News Analyses Filed Under: Orthopaedics

Articular cartilage injury is common, and it is common especially in younger, sports active people. Articular cartilage injury is followed by a long history of joint problems most probably ending in arthritis of the envolved joint, most often the knee joint. The repair of articular cartilage defects...

I just wrote on the drug.  This analysis is solely on the trial design.

Osteoarthriitis is a chronic condition. We try to use Tylenol like products to avoid side effect of NSAIDS. Tylenol itself is not without issue. In many cases it may not work. We then need to use a NSAID . Long term use leads to BP issues and renal issues. There are also the potential bleeding problems....

- this drug is a real breakthough - mechanism of action is totally   different from all other forms of therapy for osteoarthitis of knee - the possibility exists that it could be used for osteoarthritis of ALL   injectable joints, greatly enlarging it's potential market

Anesiva's Adlea showed pain relief for 12 weeks with a single 1 mg (?ml) injection.  The question is, how does it compare with the competition.

Pharmacokinetic studies of Adlea showed that when it is locally administered to the site of pain, there appears to be limited systemic exposure. Its short duration of systemic exposure (hours) relative to the long duration of analgesia (12 weeks) resulting from a single treatment course of Adlea is...

This is only a 4 week study and indeed shows an improvement in blood pressure. As osteoarthritis is a long term, chronic problem, long term results are needed. What happens to renal function and bleeding issues long term need to be addressed as well.

There has been no oral calcitonin formulation on the market as adequate delivery has been an issue. The use of intranasal for osteoporosis, is at best, a poor substitute for other agents on the market. It is interesting that there is no study on its use for osteoporosis. It is unclear why it should...

The introduction of VG2 Vertigraft is not likely to make a significant contribution to the performance of DePuy Spine. This product offers little significant advantage over other currently existing products.  While the TLIF procedure has been widely accepted as a useful technique in minimally-invasive...

The introduction of this retractor system will enhance the position of Globus in the arena of minimally-invasive spine surgery.  The retractor system is customizable, and addresses several of the shortcomings of other systems on the market.