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All GLG News Analyses Filed Under: Orthopaedics

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Kenneth Algazy Posted September 18, 2007
Reclast (Novartis) a Winner!!
Analysis of: Novartis Drug Curbs Repeat Hip Fractures | online.wsj.com
Author: Kenneth Algazy, Clinical Professor of Medicine University of Pennsylvania School of Medicine - CC
Yearly infusions of a Zometa relative- Reclast, in elderly patients after hip fracture, prevent repeat fractures and prolong survival. Yes!! Looks like a reasonable study and this yearly IV agent is certainly more tolerable than oral bisphosphonates with the associated killer heart burn and need to...
Posted September 18, 2007
Cytopia Compounds show potential as treatment for bone loss
Analysis of: Cytopia Compounds show potential as treatment for bone loss | www.cytopia.com.au
Author: GLG Member Program Contributor
The press -- at least that segment of medical media that covers biotechnology -- has seemingly picked up a press release issued by Cytopia and run with it. The press release proclaims how Cytopia's compound CYT645, an inhibitor of an enzyme that appears to be involved in bone resorption, may have potential...
Posted August 20, 2007
Medtronic Buys Kyphon For $3.9 Billion
Analysis of: Medtronic Buys Kyphon For $3.9 Billion | www.forbes.com
Author: GLG Member Program Contributor
Will the recent purchase of Kyphon by Medtronic signals the end of kyphoplasty? No because arcuoplasty does not restore vertebral height. Vertebroplasty, kyphoplasty and arcuoplasty essentially achieve the same goals, which brings up the question, do we need all three techniques? Arcuoplasty is the...
Keith Denkler Posted August 13, 2007
Xiaflex will dramatically replace surgery
Analysis of: The Journal of Hand Surgery Publishes Initial Phase III Data on Xiaflex (formerly known as AA4500), Auxilium's Investigational Treatment for Patients with Dupuytren's Contracture | pharmalive.com
Author: Keith Denkler, Associate Clinical Professor of Plastic Surgery UNIVERSITY OF CALIFORNIA SAN FRANCISCO
The efficacy of Xiaflex to not only open up the bent fingers of Dupuytren's, but its ability to diminish recurrence will dramatically decrease surgery rate for Dupuytren's. 
Posted August 8, 2007
Statistical Significance Versus Clinical Importance: Trials on Exercise Therapy for Chronic Low Back Pain as Example
Analysis of: Statistical Significance Versus Clinical Importance: Trials on Exercise Therapy for Chronic Low Back Pain as Example | www.ncbi.nlm.nih.gov
Author: GLG Member Program Contributor
Low back pain is a major public health problem.  While there is no single therapy that can be prescribed to every patient with this problem, the ubiquitous prescribing of physical therapy is frequently misguided.  The causes of low back pain are myriad, and the treatment algorithm needs to...
Posted August 7, 2007
Novel Oral Tablet Option For the treatment of Bone Diseases
Analysis of: Genta and Emisphere Technologies File IND with FDA for Oral Drug to Treat Bone Disease | www.pipelinereview.com
Author: Kuldeepak Sharma, President/Pharmaceutical Consultant Dr. Kuldeepak Sharma
As a pharmaceutical consultant, I think this IND will be novel groundbreaking treatment option for the treatment of bone diseases because it is one of first oral tablet formulation that enables oral absorption of gallium nitrate injection for treatment of cancer-related hypocalcaemia. Also this is unique...
Posted August 7, 2007
dupuytrens contracture
Analysis of: The Journal of Hand Surgery Publishes Initial Phase III Data on Xiaflex (formerly known as AA4500), Auxilium's Investigational Treatment for Patients with Dupuytren's Contracture | pharmalive.com
Author: David Mandel, Physician Mandel, David R Md
I am a rheumatologist and treat many pts with this  condition conservativelywewill be partcipating in an upcoming clin.trial with their injectable compound that has some very unique properties to relieve the contractures and possible avoid surgery
Posted August 1, 2007
Medtronic to Acquire Breakaway Imaging, LLC
Analysis of: Medtronic to Acquire Breakaway Imaging, LLC | wwwp.medtronic.com
Author: GLG Member Program Contributor
Medtronic will see increased sales of their navigation platform, and probably a secondary increase in thier spinal implants as a result of the acquisition of Breakway Imaging. Sales of the O-Arm have been increasing rapidly, adding to Medtronic's sucess in the field of spinal surgery
Posted July 31, 2007
CIGNA Covers CHARITE® Artificial Disc, USA
Analysis of: CIGNA Covers CHARITE® Artificial Disc, USA | www.medicalnewstoday.com
Author: GLG Member Program Contributor
As insurers continue to cover the Charite and other disc replacement products, the hope for coverage for other disc replacement technology will encourage further refinement and investment in motion preservation technology
Posted July 30, 2007
Surgeons discuss validity of SPORT data after release of spondylolisthesis arm
Analysis of: Surgeons discuss validity of SPORT data after release of spondylolisthesis arm | www.orthosupersite.com
Author: GLG Member Program Contributor
This study confirms the clinical impressions of the majority of spine surgeons.  Patients with degenerative spondylolisthesis fare better with surgery compared to non-operative management. If this study results in an increase in the utilization of fusion surgery to treat spondylolisthesis,...
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