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All GLG News Analyses Filed Under: Orthopaedics

Analyses are solely the work of the authors and have not been edited or endorsed by GLG.

Possible Impact Of Recently Reported Fractures On The Use Of Alendronate

July 18, 2008

GLG Expert Contributor

Drugs to Build Bones May Weaken Them | www.nytimes.com

1. This study may not have a big impact on the prescriptions of alendronate in the short term unless this problem is found to be more wide-spread. With the increased incidence of jaw necrosis reported earlier, physicians will carefully weigh the benefits before starting alendronate. 2. The fractures were found to be in patients who had taken alendronate for an average of 6.9 years. Physicians may consider stopping the medication after 5 years of use as most of the efficacy is seen in the earlier years of treatment anyway. 3. This type of fracture was identified only with the use of alendronate and not the other bisphosphonates. Physicians may choose to use the other medications rather than alendronate.

Fractures from Fosamax???

July 18, 2008

GLG Expert Contributor

Drugs to Build Bones May Weaken Them | www.nytimes.com

Patients may ask about this.  Haven't heard anyone yet.

Too much of a good thing

July 18, 2008

GLG Expert Contributor

Drugs to Build Bones May Weaken Them | www.nytimes.com

This report suggest that there is a point in therapy where we start seiing negative effects from the use of bisphosphanates. There needs to be guidelines on length of therapy. Too long may lead to adverse effects.

pump review

June 23, 2008

GLG Expert Contributor

ArthroCare Sets New Standard In Modern Arthroscopy - Launches New Quantum™ Pump Arthroscopy System In Europe | www.medicalnewstoday.com

Improved pump should be new standard for use in arthroscopic procedures. The proported features of this pump should be very useful for better visualization, ease of use and integrated approach.

When CMS put objectives in the blender, providers get the mash

June 4, 2008

GLG Expert Contributor

CMS ANNOUNCES DEMONSTRATION TO ENCOURAGE GREATER COLLABORATION AND IMPROVE QUALITY USING BUNDLED HOSPITAL PAYMENTS | www.cms.hhs.gov

CMS has the objective of keeping their costs down, increasing quality, protecting the Stark laws against physician referrals, and guarding against beneficiaries being enticed to receive more services than necessary.  CMS threw all these objectives into the ACE demonstration project.  The problems with the ACE demonstration project are:    1)      Providers are already suffering with negative Medicare margins, 2)      Medicare initiatives do not drive quality as much as threats of malpractice do, 3)      CMS has moved the politics of physician reimbursement away from Washington D.C. and into the hospital CEO’s office, 4)      Providers do not have assurance that the “gain” will be there to be “shared” in the future given CMS’s past actions,It is unclear how the prohibitions against beneficiary enticement and paying for physician referrals will be enforced.

Squeaking hips show risk of early adopting

May 27, 2008

GLG Expert Contributor

That Must Be Bob. I Hear His New Hip Squeaking | www.nytimes.com

The implant market is very competitive with surgeons being aggresive as early adopters to try to get a competitive edge and market themselves as using state of the art implants. This is pushed by the implant makers and often offer cooperative advertising. Alternative bearings are particularly "hot". Ceramics will probably see a decline as a result of bad press such as this. Computer navigation will IMHO also fade from popularity soon.

Direct to Consumer Marketing Fiasco

May 23, 2008

GLG Expert Contributor

That Must Be Bob. I Hear His New Hip Squeaking | www.nytimes.com

Ceramic hips, advertized as longer lasting and therefore better, actually have a shorter life if revised for stripe wear and making noise. Some surgeons felt that they should offer this type of surgery because patients were demanding it.

This acqusition, and others, represent a significant upgrade of Alphatec's portfolio

February 11, 2008

GLG Expert Contributor

Alphatec Holdings, Inc. Acquires An Exclusive Worldwide License for Innovative Dynamic Anterior Cervical Plate Technology | www.healthpointcapital.com

Alphatec product line will expand and increase their market share The cervical plate from Progressive is much more promising than the Trestle plate developed by Alphatec, and should increase sales and improve the cervical implant portfolio

Artificial Cervical Disc Looks Promising

January 25, 2008

GLG Expert Contributor

Artificial Disc Versus Fusion: A Prospective, Randomized Study With 2-Year Follow-up on 99 Patients | www.medscape.com

Outcomes in patients implanted with the artificial disc compare favorably with single level ACDF after 2 years.

Medtronic loses litigation to DePuy over polyaxial Vertex screws, what is the significance?

December 26, 2007

GLG Expert Contributor

U.S. Federal Court Issues Permanent Injunction Against Medtronic's Vertex And Vertex Max Screws | www.medicalnewstoday.com

the use of Vertex polyaxial screws is only a minor part of the spinal implant protfolio at Medtronic (MDT:NYSE).  This should not affect the bottom line to any significant extent.

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