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All GLG News Analyses Filed Under: Orthopaedics

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Posted February 11, 2008
Alphatec Holdings, Inc. Acquires An Exclusive Worldwide License for Innovative Dynamic Anterior Cervical Plate Technology
Analysis of: Alphatec Holdings, Inc. Acquires An Exclusive Worldwide License for Innovative Dynamic Anterior Cervical Plate Technology | www.healthpointcapital.com
Author: GLG Member Program Contributor
Alphatec product line will expand and increase their market share The cervical plate from Progressive is much more promising than the Trestle plate developed by Alphatec, and should increase sales and improve the cervical implant portfolio
Posted January 25, 2008
Artificial Disc Versus Fusion: A Prospective, Randomized Study With 2-Year Follow-up on 99 Patients
Analysis of: Artificial Disc Versus Fusion: A Prospective, Randomized Study With 2-Year Follow-up on 99 Patients | www.medscape.com
Author: GLG Member Program Contributor
Outcomes in patients implanted with the artificial disc compare favorably with single level ACDF after 2 years.
Posted December 26, 2007
U.S. Federal Court Issues Permanent Injunction Against Medtronic's Vertex And Vertex Max Screws
Analysis of: U.S. Federal Court Issues Permanent Injunction Against Medtronic's Vertex And Vertex Max Screws | www.medicalnewstoday.com
Author: GLG Member Program Contributor
the use of Vertex polyaxial screws is only a minor part of the spinal implant protfolio at Medtronic (MDT:NYSE).  This should not affect the bottom line to any significant extent.
Posted December 14, 2007
Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair
Analysis of: Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair | www.pipelinereview.com
Author: GLG Member Program Contributor
Ever since Hyaluronans (HA) have been around to lubricate the the knee, arthroplasties have declined significantly for OA. This implies that finding the precise material necessary to keep the knee capsule full will prevent further degeneration of the joint and eventually the ultimate answer to treat...
Posted December 3, 2007
FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis
Analysis of: FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis | www.pipelinereview.com
Author: GLG Member Program Contributor
Though Forteo did  increase the BMD greater than alendronate, It did not decrease the amount of no-veterbral fractures which lead to increased morbidity and mortality.
Posted November 30, 2007
Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair
Analysis of: Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair | www.pipelinereview.com
Author: GLG Member Program Contributor
Stem cells plus HA provide a physiologically relevant combination that has real potential in tissue repair and regenerative medicine. But the press release goes further than warranted, in implying that Chondrogen addresses the OA market as a whole. The trial specifically evaluated the effects of the...
Posted November 30, 2007
Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair
Analysis of: Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair | www.pipelinereview.com
Author: GLG Member Program Contributor
First of all, this is not a hypothesis generating study but a fishing expedition after an orthopedic procedure intervention. Maybe that's what happens when you let orthopedists loose with statistical analysis. Patients entered the study without any baseline osteoarthritis (OA) required...just a torn...
Posted November 29, 2007
Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair
Analysis of: Osiris Therapeutics Announces Positive One Year Data from Chondrogen Trial for Knee Repair | www.pipelinereview.com
Author: GLG Member Program Contributor
Possible nonoperative treatment for arthritis of the knee which effects 10's of millions of patients, with a predictable lasting effect. Could revolutionize the treatment of arthritis which currently has no predictable, lasting  nonoperative treatments.
Posted November 20, 2007
FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis
Analysis of: FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis | www.pipelinereview.com
Author: GLG Member Program Contributor
Bone density loss a known risk with exogenous corticosteroid therapy...but also sex, age, disuse, catabolic disease should factor into outcome risk for fractures as the feared outcome. Forteo(R) is currently a second line therapy for osteoporosis issues based on  cost and osteosarcoma theoretical...
Posted November 19, 2007
FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis
Analysis of: FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis | www.pipelinereview.com
Author: GLG Member Program Contributor
We know that PTH is a strong anabolic agent in the bone.  This study provides some quantitation in a head to head study of Forteo (Lilly) with Fosamax (Merck) in a population of steroid-induced osteoporosis patients.
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