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All GLG News Analyses Filed Under: Infectious Disease

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Posted November 16, 2007
MF59-adjuvanted Influenza Vaccine (Fluad®) Slashes Hospitalizations In The Elderly
Analysis of: MF59-adjuvanted Influenza Vaccine (Fluad®) Slashes Hospitalizations In The Elderly | www.medicalnewstoday.com
Author: GLG Member Program Contributor
The data presented by this Spanish study shows that an immune enhanced influenza vaccine likely decreases hospitalization by decreasing the inflammatory reaction that is associated with influenza. This is required in those with decreased immune responses,i.e., the elderly. In younger individuals it...
Posted October 31, 2007
Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response
Analysis of: Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response | www.prnewswire.com
Author: GLG Member Program Contributor
I am not impressed. I am wandering why the responces were so low in non-respoders. will be happy to discuss
Posted October 29, 2007
Sanofi Pasteur Receives FDA Approval of Meningococcal Vaccine for Children
Analysis of: Sanofi Pasteur Receives FDA Approval of Meningococcal Vaccine for Children | pharmalive.com
Author: GLG Member Program Contributor
-Menactra recently gained approval for children 2-10 years old -Unless the ACIP changes its recommended age for routine use (currently 11), this will have little impact -Most children will only need this in this expanded age range for travel to some parts of the world.
Posted October 26, 2007
Drug-Resistant Staph Germ's Toll Is Higher Than Thought
Analysis of: Drug-Resistant Staph Germ's Toll Is Higher Than Thought | www.washingtonpost.com
Author: GLG Member Program Contributor
Many are colonized with MRSA< just as with other staph, but relatively few get disease.
Posted October 26, 2007
Sanofi Pasteur Receives FDA Approval of Meningococcal Vaccine for Children
Analysis of: Sanofi Pasteur Receives FDA Approval of Meningococcal Vaccine for Children | pharmalive.com
Author: GLG Member Program Contributor
Meningococcal disease is rare but devastating, and any available method for reduction of the disease is welcome.   
Posted October 22, 2007
Drug-Resistant Staph Germ's Toll Is Higher Than Thought
Analysis of: Drug-Resistant Staph Germ's Toll Is Higher Than Thought | www.washingtonpost.com
Author: GLG Member Program Contributor
* MRSA is a serious problem in the US, particularly with the increasing spread of community acquired strains (caMRSA). * Toxins produced by many caMRSA are rapidly lethal in populations who get soft-tissue infections or sepsis from these organisms (children, elderly). * Nosocomically-acquired MRSAs...
Posted October 18, 2007
Drug-Resistant Staph Germ's Toll Is Higher Than Thought
Analysis of: Drug-Resistant Staph Germ's Toll Is Higher Than Thought | www.washingtonpost.com
Author: GLG Member Program Contributor
MRSA is a significant pathogen now spreading from the hospital into the community. Physicians need to think of this now everytime they deal with a soift tiisue infection. Not treating it properly can lead to dire consequences. Infection control schema now need to be inrtoduced into schools as well....
Posted October 15, 2007
Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine In Persons With Atopic Dermatitis/Eczema
Analysis of: Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine In Persons With Atopic Dermatitis/Eczema | www.medicalnewstoday.com
Author: GLG Member Program Contributor
The news published in the Medical News (11/10/2007) is an important piece of information on the use of IMVAMUNE(R) Smallpox Vaccine for patients with atopic dermatitis. This would definitely support the US Govt., particularly, The National Institutes of Allergy and Infectious Diseases (NIAID) unit's...
Posted October 11, 2007
Non-Inferiority Studies: What do the numbers mean, how does the FDA interpret them?
Analysis of: Efficacy of Iclaprim in Complicated Skin and Skin Structure Infections: Preliminary Results of ASSIST-1 | www.idsociety.org
Author: Joseph Bertino, Independent Consultant Bertino Consulting
A recent abstract for the 2007 Infectious Diseases Society of American (IDSA) meeting has generated some concern among financial analysts.  This non-inferiority study on iclaprim versus linezolid for treatment of complicated skin and skin structure infections showed that “The 95% CI for treatment...
Posted October 10, 2007
Crucell discovers human monoclonal antibodies for the prevention and treatment of the avian flu virus
Analysis of: Crucell discovers human monoclonal antibodies for the prevention and treatment of the avian flu virus | www.pipelinereview.com
Author: GLG Member Program Contributor
The only issue that will arise is safety. What will be the reaction to the monoclonal  antibodies and what are the potential downsides. Cost of this therapy may be limiting as well.
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