All GLG News Analyses Filed Under: Infectious Disease

Earlier Treatment Just Makes Sense

January 16, 2009

Analysis by: GLG Expert Contributor

Analysis of:AIDS treatment should start sooner, study finds | news.yahoo.com

These data will help justify earlier treatment of patients infected with HIV, before damage to the immune system occurs.

Likely approval at some point soon

December 10, 2008

Analysis by: GLG Expert Contributor

Analysis of:Wyeth Submits European Marketing Authorization Application for its 13-Valent Vaccine for the Prevention of Pneumococcal Disease in Infants and Young Children | phx.corporate-ir.net

-Wyeth has submitted its new and improved pneumococcal vaccine for European approval.  Although the current product (Wyeth's Prevnar) works well, the newer version would cover more serotypes of strep pneumo. -Since the original product is Wyeth's, they've been down this road before and know what the issues are likely to be to get approval; odds are very good that the new product will get approved on the first go-round or soon after 

A welcome improvement

December 9, 2008

Analysis by: GLG Expert Contributor

Analysis of:Wyeth Submits European Marketing Authorization Application for its 13-Valent Vaccine for the Prevention of Pneumococcal Disease in Infants and Young Children | phx.corporate-ir.net

With the introduction of Prevnar, there has been a dramatic decline in invasive pneumococcaal disease in young children that has had a herd immunity effect on all ages.  There has been a bit of a compensatory increase in serotype 19A disease (not in the current formulation of Prevnar).  This new vaccine will add another six serotypes of protection, including 19A that will give us another weapon against the villain microbes.

Approval Likely

December 9, 2008

Analysis by: GLG Expert Contributor

Analysis of:Wyeth Submits European Marketing Authorization Application for its 13-Valent Vaccine for the Prevention of Pneumococcal Disease in Infants and Young Children | phx.corporate-ir.net

This vaccine marks an improvement on the currently available pneumococcal vaccine for infants and children, which covers seven pneumococcal serotypes. Some of the additional serotypes have been increasing in prevalence since the seven types in the current vaccine have decreased, and it is logical to continue to aim at preventing new threats.

A Recipe for Overuse of Anti-influenza Drugs

November 17, 2008

Analysis by: GLG Expert Contributor

Analysis of:U.S. looks at whether home drug stockpiles for flu pandemic makes sense | canadianpress.google.com

There are many illnesses which people call "the flu." Not every illness with fever, aches and congestion is influenza, the only disease which these anti-virals will help.

Potential Windfall for Oral Anti-virals, will Pandemic Vaccine Manufacturers get to Benefit?

November 5, 2008

Analysis by: GLG Expert Contributor

Analysis of:U.S. looks at whether home drug stockpiles for flu pandemic makes sense | canadianpress.google.com

Vaccine manufacturers should rush for a seat at the table as this issue gets discussed. While the formulation of Tamiflu makes it easy to take, pandemic vaccines now in development should be considered for similar treatment.

Your doctor doesn't get a flu shot WHY????

November 4, 2008

Analysis by: GLG Expert Contributor

Analysis of:Flu shots a tough sell to health care workers | ap.google.com

-A recent informal survey found that many docs and nurses (60% of healthcare workers overall) don't get an annual flu vaccine, despite proven efficacy, easy availability at their place of work, and risk of contagion to patients and colleagues.  -This puts some of the most vulnerable patients at risk of absolutely preventable illness and leaves hospitals liable to claims of medical negligence. -Healthcare emplyers such as hospitals need to take a firmer stand against casual deferral and to start putting patients first.

Stockpiling flu vaccines at home will never make sense given Americans' sensibilities

November 3, 2008

Analysis by: GLG Expert Contributor

Analysis of:U.S. looks at whether home drug stockpiles for flu pandemic makes sense | canadianpress.google.com

Most American families are not familiar with signs and symptoms of influenza.  Asking them to use (and not use) a home supply of antivirals would be insanity, stretching thin the amount of antivirals available and depriving them to those in true need.  To ask them to use these meds appropriately for their children would be even more insane - at the first viral URI of the season the meds would be gone and parents would be on the phone for more, convinced that they had successfully fended off avian flu and eager to do it again. 

Vaccinate smokers?? what is the agenda and the employer of "The Advisory Committee on Immunization Practices."

October 23, 2008

Analysis by: GLG Expert Contributor

Analysis of:Panel Calls for Vaccine for Adult Smokers | online.wsj.com

31 million more doses of Pneumovax yearly in the US??

C. difficile infection not neccesarily related to antibiotics.

October 13, 2008

Analysis by: GLG Expert Contributor

Analysis of:C. Difficile And Antibiotics Not Necessarily Linked, Study Finds | www.sciencedaily.com

The key point in this article is that the author shows a connection between Community Acquired clostridium difficile infections & lack of antimicrobial use. For example, the widespread use of ant-acids ie; proton pump inhibitors. This article is helpful because delineating some of the risk factors may help curb this deadly disease. However, make no mistake there is a very clear link between hospital or nosocomial transmission & antibiotic use. All patients with diarrhea requiring hospital admission (especially with a profoundly elevated white blood cell count) should be tested for C. difficile.

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