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All GLG News Analyses Filed Under: Infectious Disease

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Posted February 15, 2007
Expect changes in influenza immunization next year
Analysis of: Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children | content.nejm.org
Author: GLG Member Program Contributor
Data confirms the safety and effectiveness of Live Attenuated influenza vaccine for children age 12 to 59 months of age.  54 percent fewer cases of culture confirmed influenza occurred in a group receiving the live attenuated vaccine.Higher rates of hospitalization occurred in the 6 to 11 month...
Posted February 14, 2007
Rotateq may be associated with intussusception
Analysis of: FDA Public Health Notification: Information on RotaTeq and Intussusception | www.fda.gov
Author: GLG Member Program Contributor
-Rotateq is a second-generation vaccine to prevent rotavirus. Merck is now working with governments across the world to try to expand its use.-The prior product was pulled off the market due to an association with intussusception.  -The FDA is analyzing case reports of infants developing intussusception...
Posted February 12, 2007
Disappointing but I think we'll get there yet....
Analysis of: Tests of Drug to Block H.I.V. Infection Are Halted Over Safety | www.nytimes.com
Author: GLG Member Program Contributor
"Topical Microbicides" refers to agents applied topically (in vagina, in condom, etc) to prevent HIV and other STD. This article refers to the halting of two studies of a microbicide called cellulose sulfate, which had previously showed promise. However, in one trial women applying it into vagina before...
Posted February 12, 2007
Treatment of African trypanosomiasis
Analysis of: Immtech Completes Enrollment in Phase III Pivotal Trial of Pafuramidine for African Sleeping Sickness | www.pipelinereview.com
Author: GLG Member Program Contributor
Pafuramidine is an exciting new drug for the treatment of the early stage of sleeping sickness. If it proves to have good activity against African trypanosomiasis, then this would become the first and only orally bioavailable drug available for the treatment of this neglected disease. New treatments...
Posted February 5, 2007
Governmental intervention will make vaccines cheaper and more readily available
Analysis of: Vaccine Makers Receive Immunity From the U.S. | online.wsj.com
Author: GLG Member Program Contributor
The law above will encourage many companies to re-enter the vaccine market which they deserted because of fear of litigation, which has been mostly frivolous.This will soon abolish the problems with Flu vaccine shortage and may also break monopoly and lead to cheaper vaccines.
Posted February 5, 2007
About time
Analysis of: Vaccine Makers Receive Immunity From the U.S. | online.wsj.com
Author: GLG Member Program Contributor
We can prevent better than we can cure sometimes. Because of litigation many companies have left the vaccine market. This should help.
Posted February 5, 2007
Pentacel not the first 5-in-1 vaccine out there. GSK got there first!
Analysis of: FDA Advisers Endorse Childhood Vaccine | users1.wsj.com
Author: GLG Member Program Contributor
- Pentacel is Sanofi's entry into the new multiple-antigen market- The space is already occupied by Glaxo's Pediarix, which covers almost the same diseases but was approved in the US 2 years ago.- There's room for both, but both will need successors as desire grows for a single all-in-one "supershot"...
Posted February 5, 2007
US Government Encouraging More Players onto Field in Vaccine Game
Analysis of: Vaccine Makers Receive Immunity From the U.S. | online.wsj.com
Author: GLG Member Program Contributor
-Action was taken this week to remove the potential of lawsuits over side effects from drug companies developing avian flu vaccines-This is one of the few inducements that Washington can give that matters to pharmaceutical makers that may encourage them to either get into research for flu drugs or to...
Posted February 1, 2007
Think resistant
Analysis of: Clinical and epidemiologic characteristics can not distinguish community-associated MRSA infection from MSSA infection. | www.journals.uchicago.edu
Author: GLG Member Program Contributor
With our use and overuse of antibiotics, we now have various resistant organisms, including MRSA. We now need to use drugs that work against this form of staph, if staph is suspected. We are still fortunate that we have oral agents and IV agents that work and are not solely dependent on Vanco or other...
Posted January 29, 2007
Empiric use of antibiotics against MRSA
Analysis of: Clinical and epidemiologic characteristics can not distinguish community-associated MRSA infection from MSSA infection. | www.journals.uchicago.edu
Author: GLG Member Program Contributor
1. In the Emergency Department or in an admitting ward, physicians must decide if a patient with a presumed staphylococcal infection has MRSA or methicillin susceptible Staph, and choose antibiotics accordingly.2. This study suggests that it is impossible to tell clinically - therefore, empiric antibiotics...
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