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All GLG News Analyses Filed Under: Infectious Disease

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Posted March 9, 2007

Roche files application in Europe for Tamiflu 30 and 45 mg capsules
Analysis of: Roche files application in Europe for Tamiflu 30 and 45 mg capsules | www.pipelinereview.com
Author: GLG Member Program Contributor

* Tamiflu works in a different way than flu vaccine, preventing the ability of virtually all flu viruses to spread throughout the body* Flu vaccines, by contrast, need to be customized to the specific strain of flu, which changes every year. Thus, the ability to stockpile vaccine in advance of...

Posted March 9, 2007

New studies indicate GSK's pre-pandemic influenza vaccine can protect against different strains of H5N1
Analysis of: New studies indicate GSK's pre-pandemic influenza vaccine can protect against different strains of H5N1 | www.pipelinereview.com
Author: GLG Member Program Contributor

Preclinical and in-vivo human data from 2 separate trials show that GSK's new Influenza vaccine offer protection against several strains of H5N1 strains, even those not contained in the vaccine.Adding this vaccine could increase manufacturing capacity of anti-influenza vaccines...

Posted March 9, 2007

Cytheris Releases Promising Clinical Data on its Interleukin-7 Immune Enhancer at the 2007 CROI Meeting in Los Angeles
Analysis of: Cytheris Releases Promising Clinical Data on its Interleukin-7 Immune Enhancer at the 2007 CROI Meeting in Los Angeles | www.pipelinereview.com
Author: GLG Member Program Contributor

Short term data look good. But, to paraphrase wall street, for long term therapy, this will have to climb a wall of skepticism

Posted March 6, 2007

New Data Support Alphavax's Vaccine For CMV
Analysis of: New Data Support Alphavax's Vaccine For CMV | www.pipelinereview.com
Author: GLG Member Program Contributor

A new vaccine for CMV has been tested in a guinea pig model. The implication is that this vaccine may be effective in humans when tested in a clinical trial.

Posted March 5, 2007

Health Experts Bet On Spread Of Bird Flu
Analysis of: Health Experts Bet On Spread Of Bird Flu | www.cbsnews.com
Author: GLG Member Program Contributor

This is a well thought experiment that will disseminate information from experts and help monitor Bird Flu more accuratelyThis project will benefit Pharmaceutical companies as well as governmental enterprises in their efforts to develop an effective vaccine more quickly

Posted February 21, 2007

FDA Restricts Use of Antibiotic
Analysis of: FDA Restricts Use of Antibiotic | www.therapeuticsdaily.com
Author: GLG Member Program Contributor

Ketek is one of many different antibiotics that can be used to treat respiratory infections. Why use a more toxic one than a safer one?

Posted February 21, 2007

FDA Restricts Use of Antibiotic
Analysis of: FDA Restricts Use of Antibiotic | www.therapeuticsdaily.com
Author: GLG Member Program Contributor

With significant drug interactions, it is surprising that the FDA took so long in resticting the drug's use. Other drugs that have had drug interactions, with the statins, have faired the same fate. Only because of its usefulness in Pneumococcal resistance will it remain indicated for significant...

Posted February 16, 2007

IL-7 May Protect T Cells in Patients With HIV-1 Infection
Analysis of: IL-7 May Protect T Cells in Patients With HIV-1 Infection | www.medscape.com
Author: GLG Member Program Contributor

IL-7, a natural cytokine (growth factor) has a protective effect on T-cells, CD 4 and CD8 cells , as well as blood mononuclear cells in HIV patients. The effect was most pronounced in patients with severe immunosuppressionWhether this translates to clinical benefit is in question because of toxicity and...

Posted February 16, 2007

FDA Restricts Use of Antibiotic
Analysis of: FDA Restricts Use of Antibiotic | www.therapeuticsdaily.com
Author: GLG Member Program Contributor

Ketek is becoming increasingly irrelevant due to safety concerns.

Posted February 15, 2007

Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children
Analysis of: Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children | content.nejm.org
Author: GLG Member Program Contributor

Data confirms the safety and effectiveness of Live Attenuated influenza vaccine for children age 12 to 59 months of age. 54 percent fewer cases of culture confirmed influenza occurred in a group receiving the live attenuated vaccine.Higher rates of hospitalization occurred in the 6 to 11 month...

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