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All GLG News Analyses Filed Under: Endocrinology

Analyses are solely the work of the authors and have not been edited or endorsed by GLG.
Analysis of: Merck's Investigational MK-0524 Significantly Reduced Flushing Caused By Extended-Release Niacin in Phase II Study | biz.yahoo.com
This article is important as it highlights the many benefits of the Niacin drugs.  It describes how MK-0524 may significantly increase adherence as it reduces the side effect of flushing.  This article describes preliminary trials with the new formulation clearly showing a reduction in the...
November 22, 2006
Epo vs Suffering?
Analysis of: Heart Risk Seen in Drug for Anemia | www.nytimes.com
The question implies that giving less erythropoietin (Epo) preparations will increase the suffering of patients with renal failure due to not having their hemoglobins (Hgb) returned to "normal." WRONG. All that is being advised is that clinicians be careful and not increase the Hgb to normal...
Analysis of: Heart Risk Seen in Drug for Anemia | www.nytimes.com
ESA agents have drastically changed management of anemiaESA agents have gotten a bad reputation
Analysis of: Merck's Investigational MK-0524 Significantly Reduced Flushing Caused By Extended-Release Niacin in Phase II Study | biz.yahoo.com
"There was no difference in lipid response when MK-0524 with ERN was compared to treatment with ERN alone." However.......
November 20, 2006
Niacin and flushing
Analysis of: Merck's Investigational MK-0524 Significantly Reduced Flushing Caused By Extended-Release Niacin in Phase II Study | biz.yahoo.com
As a physician who tries to use niaspan in pts to lower trigs and raise HDL. I have a hard time getting pts to tolerate the drug. If this new drug works, it will be very helpful in my practice.
Analysis of: No Scientific Evidence Supporting Effectiveness or Safety of Compounded Bioidentical Hormone Therapy | www.acog.org
Important is not the right word for the ACOG article in question. More important is a sound and solid scientific debate about the issue.
Analysis of: No Scientific Evidence Supporting Effectiveness or Safety of Compounded Bioidentical Hormone Therapy | www.acog.org
The article represents a very limited snapshot of the bioidentical hormone therapy market potential. Industry will have to push the FDA to perform its perfunctory duties assuring safety and efficacy of the bioidentical hormone therapies.     
Analysis of: Merck's Investigational MK-0524 Significantly Reduced Flushing Caused By Extended-Release Niacin in Phase II Study | biz.yahoo.com
- Flushing and pruritis associated with niacin is common and may be very uncomfortable leading to discontinuation of drug and usually substitution with statin- This drug would compete with statins, not Niaspan
Analysis of: No Scientific Evidence Supporting Effectiveness or Safety of Compounded Bioidentical Hormone Therapy | www.acog.org
ACOG raises very important questions on "bioidentical" hormones.
Forrest Rubenstein, MD, Cardiac, Thoracic and Vascular Surgeon
Rubenstein Cardiovascular and Thoracic Surgery
Analysis of: Acomplia (Rimonabant) - Investigational Agent for the Management of Obesity | www.drugdevelopment-technology.com
Rimonabant is a novel CB1 inhibitor which blocks the endogenous endocannibinoid receptor that leads to overeating.Rimonabant has been shown to cause a much greater weight loss than previous medications without any of the serious side effects seen with them to date.These results have been sustained for...
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