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All GLG News Analyses Filed Under: Endocrinology

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Posted June 11, 2007
Avandia/Actos and Phen/Fen: Overlapping Fates
Analysis of: U.S. urges strongest warning on 2 diabetes drugs | www.iht.com
Author: GLG Member Program Contributor
A/A and Phen/Fen have disturbing similarities. Black box warnings have been shown to hurt sales, and two seem on the horizon here. Other diabetes drugs and makers are less troubled.
Posted June 11, 2007
Curb your enthusiasm- a cautionary tale about new diabetes drugs.
Analysis of: U.S. urges strongest warning on 2 diabetes drugs | www.iht.com
Author: GLG Member Program Contributor
In the fight to control diabetes while avoiding the use of insulin, many internists have turned to a class of diabetes drugs called "glitazones".  Also called insulin sensitizers, these drugs have demonstrated efficacy, especially when used in combination with the other older agents.  By controlling...
Posted June 6, 2007
Inhalable insulins are too difficult for most patients
Analysis of: Insulins - Inhalable insulins unlikely to become blockbusters | www.pipelinereview.com
Author: GLG Member Program Contributor
Inhalable insulin is a great theoretical idea but it breaks down in practice The inhalation unit is too bulky to carry around easily. Pts. with low IQ have a hard time determining how many mg to use. There is worry about absorption of insulin if they have a cold or are coughing a lot.
Posted June 4, 2007
Bad news for Avandia and Glaxo
Analysis of: Heart Attack Risk Seen in Drug for Diabetes -- Avandia | www.nytimes.com
Author: GLG Member Program Contributor
Even though the study in the NEJM was a meta-analysis, just the possibility of an association between Avandia and increased cardiovascular risk spells bad news for Glaxo.  Physicians will be inclined to fear that Avandia will be looked upon as another Vioxx, and thus will be inclined to change...
Posted June 4, 2007
Inhaled insulin: A drug for a loyal few
Analysis of: Insulins - Inhalable insulins unlikely to become blockbusters | www.pipelinereview.com
Author: GLG Member Program Contributor
The future of diabetes care is steering towards novel oral and injectable agents, islet transplants and artificial pancreases. Insulin use in Type 2 diabetic patients may wane, and for Type 1, newer technologies will supplant the need for injections or inhalations.
Posted June 4, 2007
Slim chance for a big impact
Analysis of: Insulins - Inhalable insulins unlikely to become blockbusters | www.pipelinereview.com
Author: GLG Member Program Contributor
Inhaled insulin has a slim chance of making a big impact in the U.S. market for a number of reasons.  There are questions regarding long-term safety that remain unanswered, especially amongst those with underlying pulmonary disease.  Injectable insulin has a track record of proven efficacy,...
Posted May 28, 2007
The New Pen Saves Lantus
Analysis of: FDA Approves Lantus SoloStar(R) A New Prefilled Disposable Insulin Pen For Use With LANTUS(R) In People With Type 1 And Type 2 Diabetes | www.medicalnewstoday.com
Author: GLG Member Program Contributor
The original Lantus pen was difficult to use and malfunctioned frequently.  This was troublesome for patients and physicians.
Posted May 28, 2007
Need to Limit Access to Competitive Foods
Analysis of: Need To Establish School Nutrition Standards And Limit Access To Competitive Foods | www.medicalnewstoday.com
Author: GLG Member Program Contributor
The schools need to limit access to competitive foods.  This was discussed at a round-table forum at the PAS meeting in Toronto.
Posted May 28, 2007
The Eli Lilly (LLY) MEMOIR pen is a leap forward in diabetes care
Analysis of: Lilly Introduces World's First Digital Insulin Pen With Memory | www.medicalnewstoday.com
Author: GLG Member Program Contributor
The MEMOIR pen is a great leap forward in diabetes care.  It will definitely increase patient compliance with insulin injections.
Posted May 22, 2007
Avandia is safe and effective, when used correctly
Analysis of: Rosiglitazone Does Not Adversely Affect Cardiac Function in Type 2 Diabetics With Heart Failure | www.medscape.com
Author: GLG Member Program Contributor
Avandia is not toxic to the heart. However, in patients where fluid retention may be a problem, this class of medications ought to be avoided.
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