All GLG News Analyses Filed Under: Endocrinology

This is exciting news about the improvement in patient outcomes. it is unfortunate that they decdied to end the trial early however as with  just 41 patients in the trial - any adverse events that the treatment might cause may arise during wider usage.

SO FAR THE REVASCULARISATIONS ARE SURGICAL OR THROUGH ANGIOPLASTY . IF THIS TRIAL HAPPENS TO STAND ITS PROMISES IT WILL REPLACE THE BYPASS OR ANGIOPLASTY BY A SIMPLE INTRA MUSCULAR INJECTION . IT WILL TREAT LIMB CORONARY ISCHEMIA SIMPLY . IT WILL HAVE SO TO DEMONSTRATE ITS INOCUITY IN CANCER DEVELOPMENT...

If this vaccine indeed can show sustained results in long term studies, it will revolutionize how we can treat hypertension. I would await futher studies though.

This is the first of many drugs, that despite many attributes will not pass panel approval because of side effects whose severity and morbidity and possible mortality are unclear.

The issue of edema induction and possible worsening of CHF have been known for a long time. The implications from the NEJM meta -analysis regarding increased cardiac death from AVANDIA is much more  troubling.

You can find about any result you want to find with retrospective analysis. 

The FDA has now mandated a black box warning regarding the risk of heart failure related to the drugs Avandia and Actos (Glaxo Smith Kline and Takeda).  This comes after a highly publicized article in the New England Journal of Medicine that assessed the risk of heart disease and death in patients...

The recent meta-analysis published in the New England Journal of Medicine suggests an increased risk of myocardial infarction in patients taking rosiglitazone (Avandia).  Additionally, there was an increased risk of death, but it did not reach stastistical significance.  Black-box warnings are...

When chemicals are required to intervene in complex physical functions such as digestion and conversion of food to energy, a warning of the possible side effects is essential. Many individuals are uninformed about the process of food conversion, caloric energy values, glucose utilization,...

Avandia and Actos can contribute to heart failure.  This is old news and should be known by all prescribers of these medications. Black Box warnings do not address the underlying cause of inappropriate prescriptions. Education and electronic auditing do.