All GLG News Analyses Filed Under: Cardiology

It appears from the breifing documents that the FDA has concerns about the CV safety of Avandia. They appear to be less concerned about the CV safety of Actos but both drugs are associated with an increase risk of heart failure. It is unknown how the Advisory Committee will vote but based on the available...

Fexofenadine-Allegra is usually perceived as slightly less effective than Claritin for seasonal allergic rhinitis. Both of these drug are non-sedating. Zyrtec, however, with slight sedation potential is the most powerful of the group.

I have been working on a cell transfer device designed to optimize wound healing after PRK laser vision correction. Essentially, we plan to coat a silicone hydrogel contact lens with a thin dissolvable layer of collagen on the concave surface. Cultured epithelial cells would be seeded onto the collagen...

Resveratrol might indeed be a block buster compound due to a variety of its properties the lease of which might be its powerful antioxidant properties. This compound probably best explains the FRENCH PARADOX, which is that despite the consumption of high fat dense caloric food consumed by rich French...

Factor IX is also a promising target, as it is unique in carrying the coagulation signal from the site of injury with tissue factor activation, to the surface of platelets, where propagation and amplification of coagulation actually occur. REG1 (Regado Biosciences), a highly specific, actively reversible...

The title of the article should read New Method Of Adult Stem Cell Growth Treats Corneal EPITHELIAL Disorders.  The stem cells discussed are epithelial stem cells.  I can see this being useful in many disorders such as Stevens Johnson, Pemphigoid, Alkali burns etc.

Though this compound may have some more effect on insulin resistance and proteinurea than compounds alrady on the market, will it make a clinically significant difference? Without that, it will likely only be a "me-too" drug.

The addition of two drugs that work on the same system may indeed lead to better BP control. Hyperkalemia may be a big issue.  The question really is?  Will this be a better combo than adding a diuretic to either agent?

This study confirms previous studies that have shown that antiplatlet agents work to reduce the burden of cardiovascular disease while anticoagulants do not.

This article reports on experimental research that involves procuring stem cells from the cornea, growing them outside the eye, and then transplanting them to the diseased eye. Although this is exciting, it is quite early in the experimental stages and its application is limited to certain corneal diseases....