All GLG News Analyses Filed Under: Cardiology

"The FDA announced that studies of two prescription proton-pump inhibitors, omeprazole (Prilosec) and esomeprazole (Nexium), had raised concerns about their cardiovascular safety. In the same announcement, the agency said its preliminary assessment was that the problems seen in those studies were "not...

- The FDA is under significant scrutiny and pressure following slow dissemination of new data regarding the safety of COX-2 inhibitors (ie-Vioxx) and the "-glitazones" (Avandia/Actos) - PPIs are among the most widely used medications wordwide (mostly prescribed) with tens on millions of users annually,...

Risks outweigh the benefits of DXM and pseudoephedrine.

- dextromethorphan and pseudoephedrine have been proven to cause   rare, but serious and sometimes fatal reactions in infants - the FDA proposes putting a warning that drugs should only be   used under the direction of a physician - no physician is going to know which child will suffer...

The combination of steroids and calcitonin for inflammatory diseases is reminiscent of CombinatoRx's approach. 

The addition of a second cryothermal ablation ssytem offers an alternative to the current standard ablation systems which utilize radiofrequency energy. Important points: 1. Enhanced Safety due to both the lack of heat related injury and the reversibility of lesions that temporarily damage vital electrical...

Embolic disease caused by atrial fibrillation is better prophylaxed by anticoagulation. Carotid disease does just as well or better with antiplatlet therapy.

Ten years ago  before drug-eluting era, according to A. Colombo to diminish the stent restenosis three are 3 rules; balloon/artery ratio must be 1.1,  stenting with high deployment pressure and using IVUS. These recommedations are still in common use and stents...

Pathological data from the University of Minn. soon to be published appear to indicate that various stent problems both acute and late appear to center around chronic inflamation processes in the vessel adjacent to the deployed stent.  Chronic inflamation is directly correlated with inflation...

Safety and extreme efficacy are what MDs thqat treat Asthma are searching for.  Not a novel approach , but rather a sure, safe bet.  Jacqueline Proner, MD  Board Certified Allergist/ Immunologist  Private Practice Queens, NY