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All GLG News Analyses Filed Under: Cardiology

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Posted August 15, 2007
Unigene in-licenses potential therapies for inflammation and cardiovascular disease from University of London
Analysis of: Unigene in-licenses potential therapies for inflammation and cardiovascular disease from University of London | www.pipelinereview.com
Author: GLG Member Program Contributor
The combination of steroids and calcitonin for inflammatory diseases is reminiscent of CombinatoRx's approach. 
Posted August 6, 2007
CryoCor Receives FDA Approval For Right Atrial Flutter
Analysis of: CryoCor Receives FDA Approval For Right Atrial Flutter | www.medicalnewstoday.com
Author: GLG Member Program Contributor
The addition of a second cryothermal ablation ssytem offers an alternative to the current standard ablation systems which utilize radiofrequency energy. Important points: 1. Enhanced Safety due to both the lack of heat related injury and the reversibility of lesions that temporarily damage vital electrical...
Posted August 1, 2007
Oral Anticoagulants Trump Antiplatelet Therapy for Primary Stroke Prevention In Nonvalvular AF
Analysis of: Oral Anticoagulants Trump Antiplatelet Therapy for Primary Stroke Prevention In Nonvalvular AF | www.medscape.com
Author: GLG Member Program Contributor
Embolic disease caused by atrial fibrillation is better prophylaxed by anticoagulation. Carotid disease does just as well or better with antiplatlet therapy.
Posted July 30, 2007
Scrutiny of Stent Problems Turns to Doctors
Analysis of: Scrutiny of Stent Problems Turns to Doctors | online.wsj.com
Author: GLG Member Program Contributor
Ten years ago  before drug-eluting era, according to A. Colombo to diminish the stent restenosis three are 3 rules; balloon/artery ratio must be 1.1,  stenting with high deployment pressure and using IVUS. These recommedations are still in common use and stents...
Posted July 26, 2007
Scrutiny of Stent Problems Turns to Doctors
Analysis of: Scrutiny of Stent Problems Turns to Doctors | online.wsj.com
Author: GLG Member Program Contributor
Pathological data from the University of Minn. soon to be published appear to indicate that various stent problems both acute and late appear to center around chronic inflamation processes in the vessel adjacent to the deployed stent.  Chronic inflamation is directly correlated with inflation...
Posted July 26, 2007
Amira Pharmaceuticals Starts First Clinical Trial of Lead Compound With Potential in Asthma and Cardiovascular Disease
Analysis of: Amira Pharmaceuticals Starts First Clinical Trial of Lead Compound With Potential in Asthma and Cardiovascular Disease | www.pipelinereview.com
Author: GLG Member Program Contributor
Safety and extreme efficacy are what MDs thqat treat Asthma are searching for.  Not a novel approach , but rather a sure, safe bet.  Jacqueline Proner, MD  Board Certified Allergist/ Immunologist  Private Practice Queens, NY
Michael Davidson Posted July 25, 2007
What are the potential ramification for Avandia following the FDA Advisory Committee?
Analysis of: FDA Advisory Committee on The Cardiovascular Ischemic/thrombotic Risks of Rosiglitzone | www.ncbi.nlm.nih.gov
Author: Michael Davidson, Director, Preventive Cardiology The University of Chicago
It appears from the breifing documents that the FDA has concerns about the CV safety of Avandia. They appear to be less concerned about the CV safety of Actos but both drugs are associated with an increase risk of heart failure. It is unknown how the Advisory Committee will vote but based on the available...
Posted July 25, 2007
Ranbaxy Receives Tentative FDA Approval For Fexofenadine Hydrochloride Tablets
Analysis of: Ranbaxy Receives Tentative FDA Approval For Fexofenadine Hydrochloride Tablets | www.medicalnewstoday.com
Author: GLG Member Program Contributor
Fexofenadine-Allegra is usually perceived as slightly less effective than Claritin for seasonal allergic rhinitis. Both of these drug are non-sedating. Zyrtec, however, with slight sedation potential is the most powerful of the group.
Paul Chen Posted July 25, 2007
Cell Transfer Device for Corneal Wound Healing
Analysis of: New Method Of Adult Stem Cell Growth Treats Cornea Disorders | www.sciencedaily.com
Author: Paul Chen, Ophthalmologist North County Laser Eye Associates
I have been working on a cell transfer device designed to optimize wound healing after PRK laser vision correction. Essentially, we plan to coat a silicone hydrogel contact lens with a thin dissolvable layer of collagen on the concave surface. Cultured epithelial cells would be seeded onto the collagen...
Posted July 25, 2007
Uncorking the Secret to a Healthy Life - Two Scientists Attempt to Control Aging Using Resveratrol, a Compound Found in Red Wine
Analysis of: Uncorking the Secret to a Healthy Life - Two Scientists Attempt to Control Aging Using Resveratrol, a Compound Found in Red Wine | abcnews.go.com
Author: GLG Member Program Contributor
Resveratrol might indeed be a block buster compound due to a variety of its properties the lease of which might be its powerful antioxidant properties. This compound probably best explains the FRENCH PARADOX, which is that despite the consumption of high fat dense caloric food consumed by rich French...
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