Council Members in this Study Group: 82
This study group may include physicians, care providers, and researchers specializing in internal medicine, cardiology, oncology, dermatology, emergency medicine, family medicine, neurology, obstetrics-gynecology, psychiatry, radiology, nursing, optometry, genetics, and mental health. It may also include experts knowledgeable on diagnostic labs, disease management, medical devices, long term care, surgery centers, health management, pharma, and biotechnology, among others.
Leading institutions connect with members of this Study Group through GLG
Orthopaedic Surgeon
Hospital of the University of Pennsylvania - CC![]()
Samir Mehta, MD, is an orthopaedic surgeon at the Hospital of the University of Pennsylvania. Previously, he was an Instructor at Harborview Medical Center and Orthopaedic Surgeon and Assistant Professor of Orthopaedic Surgery in the Division of Orthopaedic...
Associate Spine Surgeon
Heartland Hand and Spine Orthopedic Center![]()
Alexander Bailey, MD, is Medical Director of Heartland Spine & Specialty Hospital and a board certified Associate Spine Surgeon at the Heartland Hand & Spine Orthopedic Center in Kansas. Dr. Bailey practices at three area hospitals including a privately...
Director of Spine Services
HOSPITAL FOR JOINT DISEASES ORTHOPAEDIC INSTITUTE![]()
Jeffrey Goldstein, MD, is Director of the Spine Service and Associate Director of the Spine Fellowship at NYU Hospital for Joint Diseases. Dr. Goldstein is Associate Professor of Orthopaedic Surgery at NYU School of Medicine. His surgical interests include...
Spine Surgeon
COMPREHENSIVE SPINE CARE PA![]()
Rafael Levin, MD, is a Board Certified Orthopaedic Spine Surgeon at Comprehensive Spine Care in New Jersey. Dr. Levin is an expert in lumbar and cervical disc replacements and minimally invasive decompression and fusion surgery. His clinical research...
Spine Surgeon
TEXAS BACK INSTITUTE OPERATIONS, INC.![]()
Renato Bosita, MD, MBA, is a spine surgeon at Texas Back Institute. His areas of expertise include operative and non-operative treatment of spine problems, including sciatica, herniated disks, internal disk derangement, and spinal stenosis. He is well...
Opinions and analyses expressed in GLG News are solely those of the author. See the Terms of Use for details.
TRPs as Analgesic Drug Targets: Using HC-030031 to Probe the Role of TRPA1
September 28, 2009
The 3rd Annual Pain Therapeutics Summit | click.bsftransmit1.com
Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is a cold receptor, somewhat the opposite of the capsaicin receptor (TRPV1), which is a heat receptor. TRPA1 is a chemosensor and it has an abundance of agonists, exogenous (cigarette smoke, etc...) and endogenous (prostaglandins, etc…). All neurons that express TRPA1 also express TRPV1. Stimulating TRPA1 causes pain. Hydra Biosciences is developing TRPA1 antagonists (receptor blocker) to block pain and inflammation.
TRPV1 Agonists: 500 Years in Development
September 28, 2009
The 3rd Annual Pain Therapeutics Summit | click.bsftransmit1.com
Qutenza is a flexible film that wraps on the skin and leads to a rapid release of 8% capsaicin. Possible applications: OA, Post-herpetic neuralgia, HIV neuropathy, and diabetic neuropathy. The results show efficacy in both post-herpetic neuralgia and HIV neuropathy as determine by 30% decrease in pain. More trials are being presently conducted. NeurogesX is developing a liquid form is that is works in a much shorter time (5 min instead of the current 30 to 60 min).
Antagonists: Are They Too Hot to Handle?
September 28, 2009
The 3rd Annual Pain Therapeutics Summit | click.bsftransmit1.com
Merck TRPV1 Antagonists MK-2295: Results of clinical studies and reasons why it will not make it to market MK-2295 was administered to normal individuals for 14 days. The investigator tested for heat sensitivity by applying a heat probe to the skin or the subjects having taken MK-2295 or placebo. They also immersed their hands in hot water (48 degree C) or asked them to drink hot water. The results were impressive with the subjects taking MK-2295 displaying a raised threshold to heat. The problem is that often they did do not find unpleasant temperatures around 48 degree C.
Responsive vs unresponsive depressive patients have similar electrode sites
September 7, 2009
Based on an association between successful and unsuccessful clinical response, the authors present stereotaxic coordinates, allowing standardization of the implantation site.The post-implantation analysis position of the intracerebral quadripolar electrodes was analyzed in twenty patients. Eleven out of 20 patients achieved a significant reduction of their depression scores at 1 year. The responder's electrodes were only slightly more ventral by 1-2 mm. See J Neurosurg (on line) / May 29, 2009.
Vertebroplasty vs kyphoplasty vs arcuoplasty
August 20, 2007
Medtronic Buys Kyphon For $3.9 Billion | www.forbes.com
Will the recent purchase of Kyphon by Medtronic signals the end of kyphoplasty? No because arcuoplasty does not restore vertebral height. Vertebroplasty, kyphoplasty and arcuoplasty essentially achieve the same goals, which brings up the question, do we need all three techniques? Arcuoplasty is the safest of a three for lower thoracic and lumbar vertebrae but until Medtronic comes up with a smaller injection needle system, vertebroplasty will be more appropriate for upper thoracic and cervical spinal levels. The arcuate system is market for osteoporotic fractures but could be improved for cancer (metastasis) related fracture.
March 19, 2008 | Boston
GLGi: OrthopedicsLeading Experts in Surgeons who Perform Spinal Fusions have not participated in any GLG webcasts.