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GLG News by Xolair Prescribers for Asthma (US)

Analysis of: New Options for Mild Asthma Treatment (www.foxnews.com)
If asthma triggers are identified, avoidance of same reduces "attacks".  If the asthma in question is allergic in origen, said asthma can be eliminated through allergy immunotherapy.  There is more than one way to skin a cat! I wonder about the study (which I have not read) if the demand useage...
Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
Analysis of: FDA Approves Fast Track Designation for Naryx Pharma’s Product for Chronic Sinusitis (www.naryxpharma.com)
I have not found nebulized antibiotic therapy to be of great success in patients with chronic sinusitis.  There are already a few pharmacies that have formulated an array of nebulized antibiotics and I have tried them in a few patients with no success.   
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Steroid-Free Astelin(R) Nasal Spray (R) Demonstrated Seasonal Allergy Symptom Improvement Within 15 Minutes in Clinical Study (www.drugnewswire.com)
This is one of those studies where the marketing department calls us research and says, "Here's the conclusions to your next study.  Now design and perform a study to reach these results and this conclusion."  Unfortunately, I'm not kidding, and doctors aren't fooled.Years ago, Astelin designed...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: No Additive Adrenal Suppression Seen With Intranasal Ciclesonide Added to Inhaled Fluticasone (www.medscape.com)
I think the correct way to say it is, "You can eat your cake, and have it too", but no one knows what I'm talking about. This study looked at what happens when you add a nasal steroid (ciclesonide) to someone who is already on Advair 500/50.  Please note that one of the authors has a slight,...
Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
February 27, 2007
Xolair apprehension
Analysis of: FDA Orders Black Box Anaphylaxis Warning for Omalizumab (Xolair) (www.medpagetoday.com)
There is a concern about anaphylaxis secondary to Xolair administration and this may result in longer waiting times after the administration of the drug.
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Controlled-Release Zileuton Tablets Shows Safety Profile Similar to Placebo: Presented at CHEST (www.docguide.com)
Zileuton is much more than just Singulair taken 4 times a day. Its a much better leukotriene antagonist. Its benefit is comparable to inhaled steroids, and, alone, it can improve a patients pulmonary function test results for the volume of air blown out in the first second (FEV1). Singulair and Accolate...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Low-Cost Bottle-Spacer Bronchodilator Treatment May Be Effective in Children (www.medscape.com)
This article points out that any device which holds the asthma medicine so that you can co-ordinate the puffing with the inhaling allows you to increase the percentage of the medicine that gets into your lungs.  As another reviewer correctly points out, this is very, very important in inhalers...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: FDA Orders Black Box Anaphylaxis Warning for Omalizumab (Xolair) (www.medpagetoday.com)
BACKGROUND Xolair is the first Biotech drug for allergic asthma.  It works by blocking the effect of IgE, the allergic antibody (an antibody is an infection-fighting protein that your body produces to fight foreign invaders.  An allergic response to dust mites or pollen happens because...
Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
Analysis of: Patient Treatment Completed in Phase 3 Trial of C1-Esterase Inhibitor in Hereditary Angioedema (www.ptcommunity.com)
HAE is a rare but potentially life threatening immunologic disease.  If c1 esterase inhibitor is found to be effective in preventing exacerbations of HAE than this novel treatment will have a great impact on the lives of those affected and will undoubtedly replace the present treatments such as...
Analysis of: CHEST: Statins May Retard Lung Deterioration in Smokers (www.medpagetoday.com)
1. Statins are an unusual class of pharmaceutics that have a wide range of action beyond lipid management2. Almost all current smokers place themselves at risk for coronary artery disease and have a high prevalence of hyperlipidemia3. Physicians will not likely prescribe statins for lung remodeling

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