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September 25, 2008

Narrowing the Category of "Carcinoma of Unknown Primary" Site-- still a ways to go
Analysis of: Raising the Profile of Cancer of Unknown Primary | jco.ascopubs.org
Author: GLG Expert Contributor

Diagnostic uncertainty in metastatic cancer as to the site of origin remains a problem in medicine today, albeit a slowly shrinking one. Immunohistochemistry using monoclonal antibodies from a host of makers will remain the mainstay in defining the site of origin, but it's proper use depends on accurate...

January 11, 2008

Sysmex has potential to expand current penetration and open new market
Analysis of: Sysmex Launches Automated Hematology Analyzer XE-5000 | www.medscape.com
Author: GLG Expert Contributor

Integrating conventional blood analysis with flow cytometry paves the way for penetration from the former routine testing market into the latter, specialized cancer testing market. This platform has the potential to broaden penetration by offering more test capabilities onto an existing platform....

January 9, 2008

mTCR: a biomed black swan?
Analysis of: MediGene Focuses its Research Activities and Considers External Financing for mTCR Program | www.euroinvestor.co.uk
Author: GLG Expert Contributor

The holy grail of pharmacology is specificity, inventing drugs that faithfully reach their target but do not affect other cells. Monoclonal antibodies have potential but have not yet reached that mark. Monoclonal T cell receptors (mTCR) might succeed where all other drugs have failed.

October 22, 2007

DNA-based HPV analysis might replace the Pap smear
Analysis of: Human Papillomavirus DNA versus Pap Screening Tests for Cervical Cancer | content.nejm.org
Author: GLG Expert Contributor

Although many new tests attempt to improve upon current methods of cancer diagnosis, few actually hit that mark. Typically, they take a benchmark and try to replicate it in terms of efficacy. This method, however, has the potential to become standard of care for cervical carcinoma screening....

July 6, 2007

Improved interventional pulmonology is good for patients and payors
Analysis of: Combination Of Two Bronchoscopic Techniques Greatly Improves Diagnostic Yield In Peripheral Lung Lesions | www.medicalnewstoday.com
Author: GLG Expert Contributor

Delay in diagnosis due to an inability to obtain sufficient diagnostic material from the first procedure attempted costs patients, hospitals and insurers, as progressively more invasive (and expensive) modalities are undertaken to determine the nature of a lesion. This randomized trial verifying the...

May 31, 2007

Tyrosine kinases continue to offer clues to cancer genetics and potential treatments
Analysis of: Researchers find big batch of breast cancer genes | www.cnn.com
Author: GLG Expert Contributor

This announcement opens a larger door on genetic risk, and probable pathogenesis of one of the world's most common cancers, post-menopausal breast cancer. The researchers identified a marker gene FGFR2 with a dose-related risk for developing breast cancer. FGFR appears to be a tyrosine kinase, a type...

May 29, 2007

PCR analysis offers hope of pre-event detection of public health risks in food industry
Analysis of: New Test May Allow For Rapid Detection Of Salmonella In Meat | www.medicalnewstoday.com
Author: GLG Expert Contributor

PCR is now adaptable to table-top operation by low-technical operators. This vastly expands the array of settings where its highly sensitive detection capability can be applied. The rapid results from real-time PCR can thus detect health risks to the food supply long before they are distributed. ...

May 29, 2007

May 28, 2007

Cryoablation offers significant hope for low grade and stage cancer patients
Analysis of: First Randomized Head-to-Head Study Shows Cryoablation at Least As Effective As External Beam Radiation for Treating Localized Prostate Cancer | www.medicalnewstoday.com
Author: GLG Expert Contributor

Cryosurgical options appear to offer lower morbidity options to patients with certain types of prostate cancer. This change in the risk profile of treatment will shift many cases from traditional surgery and radiation therapy, and also shift some cases from "watchful waiting" to treat.

May 28, 2007

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