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GLG News by Sutent Prescribers for RCC: Oncologists (US)

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February 20, 2008
GVAX (Cell Genesys) In Metastatic Prostate Carcinoma (MPCA). I'm Impressed So Far!
Analysis of: Cell Genesys Reports Association Between Immune Response and Patient Survival in Phase 2 Trial of GVAX Immunotherapy for Prostate Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Immunologic response translated into improved survivals in 1/2 of the trial subjects!
February 19, 2008
While Baxter and APP "fiddle" GSK's Lovenox should jump into the void
Analysis of: Baxter Rival APP Steps In Quickly To Supply Heparin | online.wsj.com
Author: GLG Expert Contributor
APP wants to jump into the void created by Baxter's "allergic" problems related to Chinese suppliers. BUT APP appears to also obtain some of it's product from China and with FDA's scrutiny I would not bet on continued supplies.
February 18, 2008
Sutent (Pfizer) causes heart failure?? Advantage Nexavar (Bayer/Onyx) and Torisel (Wyeth)
Analysis of: Kidney Cancer Drug Linked to Higher Rate of Heart Problems | www.washingtonpost.com
Author: GLG Expert Contributor
Sutent is associated with cardiac dysfunction!?
February 18, 2008
FDA allowing info on non FDA approved uses? A bonus for Pharma but a nightmare for insurers.
Analysis of: F.D.A. Seeks to Broaden Range of Use for Drugs | www.nytimes.com
Author: GLG Expert Contributor
As an oncologist we are aware of a drugs efficacy in conditions other than what it has been approved. Avastin in breast cancer; Nexavar and Erbitux in lung cancer, Taxotere in sarcomas. This list would be voluminous and would be a real benefit for patients BUT.......
February 15, 2008
"Targeted" approach in both Ovarian and endometrial tumors? Very interesting and potentially effective!
Analysis of: Æterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers | www.pipelinereview.com
Author: GLG Expert Contributor
Targeting gynecologic tumors with a "hormone" attached to an effective chemotherapeutic agent.
February 14, 2008
Rituxan: Another use for Vitamin R???
Analysis of: B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis | content.nejm.org
Author: GLG Expert Contributor
Very preliminary but if a larger study is confirmatory, and even before in the community, this agent will be used in MS.
February 14, 2008
Avastin (Genentech, Roche) in Breast Cancer: The Second Time is a Charm with the FDA???
Analysis of: In Second Trial, Avastin Is Found Effective in Treating Breast Cancer | www.nytimes.com
Author: GLG Expert Contributor
"Genentech said Tuesday that a new clinical trial had shown that its best-selling drug Avastin was effective in treating breast cancer, a finding that could increase the chances that the product will be approved for that use."
February 12, 2008
Low Molecular Weight Heparins (LMWH): a windfall!!
Analysis of: Problems in Blood Drug Lead to Halt by Factory | www.nytimes.com
Author: GLG Expert Contributor
If there is a production delay in "standard" heparin, it will open the door for LMWH preparations. Which ones? Sanofi-Aventis's Lovenox
February 11, 2008
Are second (tandem) transplants dead in MM and what does it mean to PHARMA
Analysis of: Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial | bloodjournal.hematologylibrary.org
Author: GLG Expert Contributor
Thalidomide post single stem cell transplant is as good as two transplants back to back (tandem.)
February 11, 2008
Hair follicle analysis directing cancer care- What if the chemo or mother nature leaves you bald???
Analysis of: Epistem plc and AstraZeneca Complete Plucked Hair Biomarker Study for Oncology Drug Development | www.foxbusiness.com
Author: GLG Expert Contributor
Analysis of RNA obtained from hair follicles can be used to guide drug development and therapy

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