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GLG News by Sutent Prescribers for RCC: Oncologists (US)

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April 22, 2008
Thalidomide (Celgene) use to be liberalized in Europe
Analysis of: Thalidomide Gets Boost in Europe | online.wsj.com
Author: GLG Expert Contributor
Thalidomide literally started the improved outlook in MM along with, and followed by Velcade, Revlimid and Stem Cell transplants. To now have increased access in Europe should open up that market eventhough the other agents are in widespread use (I think)
April 22, 2008
Wellpoint restricting epo products. Am I surprised?? No!!
Analysis of: WellPoint likely to follow FDA on anemia drugs | www.reuters.com
Author: GLG Expert Contributor
A major insurer (Wellpoint) is using the guidelines of the FDA to restrict erythropoietin (Epo) use.
Donald FlemingApril 21, 2008
Why Xeloda can't eliminate 5FU
Analysis of: Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer | jco.ascopubs.org
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
Xeloda has time after time demonstrated to be as good if not better than 5FU Xeloda continues to lag behind 5FU in the US Recent trial results are not likely to change things overnight
April 18, 2008
XELOX=FOLFOX! Score one for Roche!
Analysis of: Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer | jco.ascopubs.org
Author: GLG Expert Contributor
In MCRC FOLFOX which involves infusional 5FU has been the cornerstone of therapy. This study shows that an oral 5FU substitute, Xeloda, can replace the IV 5FU and expedide care and avoid cumbersome infusions.
Donald FlemingApril 16, 2008
Non small cell lung cancer has little to be excited about
Analysis of: ALIMTA(R) (pemetrexed for injection) Receives European Approval for Histologically-Based Use in First-Line Treatment of Most Common Lung Cancer | www.pipelinereview.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
Lilly will likely get front line approval for Alimta in non small cell lung cancer Most patients with advanced disease never see a response to therapy
April 15, 2008
Novartis initiated, positive in randomized phase II trial- I think they (we) may have something!
Analysis of: ASA404 begins pivotal trial to explore new approach in treating lung cancer, the leading cause of cancer death | www.pipelinereview.com
Author: GLG Expert Contributor
"ASA404 is a Tumor-Vascular Disrupting Agent (Tumor-VDA) that selectively causes the collapse of existing tumor blood supply leading to extensive tumor cell death." It is being combined with Taxol and carboplatin in a randomized phase III study.
April 15, 2008
Alimta (Lilly): Approved as First Line Agent in Europe for Non Squamous Cell Lung Ca!!!
Analysis of: ALIMTA(R) (pemetrexed for injection) Receives European Approval for Histologically-Based Use in First-Line Treatment of Most Common Lung Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Alimta will be used first line with Cis Platin as a primary therapy for non squamous non small cell lung cancer (NSCLCA)
April 14, 2008
Physician owned hospitals. Beneficial to whom? Certainly not the patient!!!
Analysis of: U.S. Reps give boost to physician-owned hospitals | www.fiercehealthcare.com
Author: GLG Expert Contributor
2 Texas U.S. Reps think that physcian owned hospitals are OK?
April 14, 2008
Co-Payments for Expensive Drugs Soar: Does Pharma really want governmental controls?
Analysis of: Co-Payments for Expensive Drugs Soar | www.nytimes.com
Author: GLG Expert Contributor
Co payments which had been $5/10/20 in the past are now a %age of the cost. When the cost may be upwards of $50-100K and you have a 20% co pay you can see the costs that are transfered back to the insured.
April 11, 2008
Genentech/Avastin: Drp in sales?? Be patient!
Analysis of: Genentech Profit Jumps By 12% on Solid Revenue | online.wsj.com
Author: GLG Expert Contributor
Has Avastin "hit the wall" as far as increased sales are concerned? Growth in the breast cancer market has not been as exuberant as expected.

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