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GLG News by Seroquel Prescribers forSchizophrenia (US)

November 24, 2008
Efficacy isn't everything
Analysis of: 2nd Generation Antidepressants Prove Effective (health.usnews.com)
This article tells you only that the drugs are equally effective, but not what that really means in real life.
Analysis of: St John's Wort 'as good as Prozac' (ukpress.google.com)
This "report" tells you nothing that you need to know in order to assess the validity of these studies.  We have always known that St. John's Wort has some effectiveness---but it certainly does not come without side-effects.  Where is the information about the length of the studies, the relative...
Analysis of: Lilly Announces Initiation of Second Global Phase III Trial of Investigational Alzheimer's Disease Compound (newsroom.lilly.com)
Gamma secretase inhibitors are one of several kinds of drugs being studied for the prevention/amelioration of Alzheimer's.  In concept they make sense.
July 31, 2008
Be very careful
Analysis of: Blood pressure drugs may protect against Alzheimer's (www.washingtonpost.com)
All is not as it seems when reported in the press, especially the non-scientific press.
Analysis of: Doctors Say Medication Is Overused in Dementia (www.nytimes.com)
We need to look to the cause of why we prescribe antipsychotics to patients with dementia.  We have very few tools to use and sometimes these drugs are a necessity.
Analysis of: Most Doctors Aren’t Using Electronic Health Records (www.nytimes.com)
This article clearly describes the Catch-22 in which most doctors, except for those employed by the large institutions, find themselves.  We cannot afford to practice the "best" medicine, and yet, if we could, we might well make fewer errors and make medical care for our patients more seamless. ...
Analysis of: Warning over drug trial’s effects on testing (www.ft.com)
Direct comparisons between potential competing agents often do not exist Initial FDA approval is usually based on comparisons to placebo A new approval does necessarily mean that the new agent is better than existing ones, although this is implied by industry Industry bears all the costs of efficacy...
Analysis of: FDA Approves AstraZeneca’s Seroquel for Maintenance Treatment in Bipolar Disorder (www.astrazeneca.com)
Specific pharmacology Borad range of indications Validation of some current prescribing patterns Possible gradual increased use of the medication
Analysis of: Abbott Scientists Present A New Approach for Treating Attention-Deficit Hyperactivity Disorder (biz.yahoo.com)
This is a potentially interesting alternative to current ADHD stimulant treatment. There is, I believe, existing literature on the efficacy of nicotine patches in the treatment of severe,otherwise intractable ADHD in children, which would seem to support these results. Of course, much work remains to...
Analysis of: Abbott Scientists Present A New Approach for Treating Attention-Deficit Hyperactivity Disorder (biz.yahoo.com)
NNR's are being heavily studied for several uses and are looking promising.

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