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GLG News by Rheumatoid Arthritis Specialists (US)

Analysis of: Drugs to Build Bones May Weaken Them (www.nytimes.com)
This should not deter the practicing physician to prescribe these agents osteoporosis will reach epidemic proportions and if we can reduce fractures by 50% the savings within the healthcare system will be enormous that's not to say that individuals albeit rare may have a propensity to develop fractures...
Analysis of: Genentech and Biogen Idec Announce Top-Line Results From Phase II/III Clinical Study of Rituxan in Systemic Lupus Erythematosus (www.pipelinereview.com)
Rituxan is no better than placebo in SLE in this study.  Another med bites the dust when tested for SLE.  Further details of this study need to be reviewed.
Dipti Doshi, MD, Rheumatologist
HEALTHCARE PARTNERS MEDICAL GROUP
Analysis of: Trubion Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Rheumatoid Arthritis (www.pipelinereview.com)
Drug therapies for RA include (NSAIDS), DMARDS, and, most recently, biologics. Biologics currently on the market for RA target immune messengers called cytokines, which promote the damaging inflammatory process, and include anti-tumor necrosis factor (TNF) drugs – infliximab , etanercept,adalimumab,...
Analysis of: Enbrel, Perception and Remicade Fostering a New Class of Drugs (www.pharmalive.com)
A delay in instituting aggressive antirheumatic medications such as the biologic response modifiers has long term implications in irreversible joint damage. Cost considerations (particularly with the looming potential of "universal healthcare" under a new administrations promises) with exponentially...
Analysis of: Galapagos announces osteoporosis collaboration with Lilly (www.pipelinereview.com)
Lilly needs new treatments and strategies  to maintain position as industry leader.
Analysis of: U.S. reviews osteoporosis drugs' effect on heart (www.reuters.com)
 In a recent hip fracture intervention trial released on the New England Journal of Medicine website by Lyles, et al on Sept 17,2007 (not scheduled to be released in print until Nov 1 2007) Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture   A placebo controlled study...
September 20, 2007
Exubera in a European study
Analysis of: New Data Support Long-Term Efficacy and Safety in Patients Who Took Exubera for Eight Years (www.pipelinereview.com)
European results in a limited number of patients on Exubera for 2-8 years Effectiveness and safety in about a 1/3 of study participants after 8 years
Analysis of: BioDiem completes treatment in phase I/II study of eye drug BDM-E: Results due November 07 (www.pipelinereview.com)
-diabetes and diabetic retinopathy is on the rise due to an increasing epidemic of obesity -diabetic retinopathy is the leading cause of blindness in the United States
Analysis of: Northwest Bio gets Swiss approval for brain cancer vaccine UPDATE (money.cnn.com)
-Brain cancer-or more specifically- glioblastomas- are uniformly fatal and treatment -radiation and chemo--is really not effective. -Many younger people are affected by this disease and a cure that is patient specific would be terrific. - This is not the first time that someone has tried to do this...
Dipti Doshi, MD, Rheumatologist
HEALTHCARE PARTNERS MEDICAL GROUP
Analysis of: Anesiva Announces Phase 2 Data Showing Substantial, Long-Term Pain Reductions with Adlea(TM) (formerly 4975) in Osteoarthritis of the Knee (www.pipelinereview.com)
Pharmacokinetic studies of Adlea showed that when it is locally administered to the site of pain, there appears to be limited systemic exposure. Its short duration of systemic exposure (hours) relative to the long duration of analgesia (12 weeks) resulting from a single treatment course of Adlea is...

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