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vWF is one of a number of attractive antiplatelet targets which include P2Y112, GIIb/IIIa, to name a few. Currently Medicines Company's Cangrelor, a small molecule against P2Y12 is quite far along in development. In addition, Archemix just published results of its Phase I trial with its anti-vWF...
Factor IX is also a promising target, as it is unique in carrying the coagulation signal from the site of injury with tissue factor activation, to the surface of platelets, where propagation and amplification of coagulation actually occur. REG1 (Regado Biosciences), a highly specific, actively reversible...
Viagra (sildenafil) a same a PDE-5 same class compound as SLx-2101 has shown efficacy for Raynaud's by significantly reducing the frequency and duration of Raynaud attacks and improved capillary flow velocity by 400%, according to a study led by Roland Fries, M.D and published online...
•Anemia has been implicated as a major factor affecting outcomes in chronic heart failure. •This FDA action will, therefore, also likely abort attempts to extend use of recombinant hematopoeitic agents to treatment of chronic heart failure.