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GLG News by Pulmonologists (US)

Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
February 27, 2007
Xolair apprehension
Analysis of: FDA Orders Black Box Anaphylaxis Warning for Omalizumab (Xolair) (www.medpagetoday.com)
There is a concern about anaphylaxis secondary to Xolair administration and this may result in longer waiting times after the administration of the drug.
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Controlled-Release Zileuton Tablets Shows Safety Profile Similar to Placebo: Presented at CHEST (www.docguide.com)
Zileuton is much more than just Singulair taken 4 times a day. Its a much better leukotriene antagonist. Its benefit is comparable to inhaled steroids, and, alone, it can improve a patients pulmonary function test results for the volume of air blown out in the first second (FEV1). Singulair and Accolate...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Low-Cost Bottle-Spacer Bronchodilator Treatment May Be Effective in Children (www.medscape.com)
This article points out that any device which holds the asthma medicine so that you can co-ordinate the puffing with the inhaling allows you to increase the percentage of the medicine that gets into your lungs.  As another reviewer correctly points out, this is very, very important in inhalers...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: FDA Orders Black Box Anaphylaxis Warning for Omalizumab (Xolair) (www.medpagetoday.com)
BACKGROUND Xolair is the first Biotech drug for allergic asthma.  It works by blocking the effect of IgE, the allergic antibody (an antibody is an infection-fighting protein that your body produces to fight foreign invaders.  An allergic response to dust mites or pollen happens because...
February 23, 2007
Cause for Concern
Analysis of: FDA Orders Black Box Anaphylaxis Warning for Omalizumab (Xolair) (www.medpagetoday.com)
The black box warning is a real concern to physicians who prescribe Xolair and patients who are taking it.  It highlights a risk that has always been there but is apparently more common than previously thought.
Analysis of: Low-Cost Bottle-Spacer Bronchodilator Treatment May Be Effective in Children (www.medscape.com)
Since the advent of the metered dose inhaler we have used many contraptions as spacer devices to allow for gas expansion, dropout of large particles and to facilitate timing of inhalation.  In this respect the bottle spacer joins pvc pipe, and toilet paper rolls in the spacer menu. ...
Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
Analysis of: Patient Treatment Completed in Phase 3 Trial of C1-Esterase Inhibitor in Hereditary Angioedema (www.ptcommunity.com)
HAE is a rare but potentially life threatening immunologic disease.  If c1 esterase inhibitor is found to be effective in preventing exacerbations of HAE than this novel treatment will have a great impact on the lives of those affected and will undoubtedly replace the present treatments such as...
Analysis of: Texas governor orders anti-cancer vaccine for schoolgirls (www.usatoday.com)
I feel if we have the option of making a major impact on the incidence of cervical cancer, Gardasil should be given at the earliest effective time period. Also, it will decrease the incidence of genital warts.
Analysis of: CHEST: Statins May Retard Lung Deterioration in Smokers (www.medpagetoday.com)
1. Statins are an unusual class of pharmaceutics that have a wide range of action beyond lipid management2. Almost all current smokers place themselves at risk for coronary artery disease and have a high prevalence of hyperlipidemia3. Physicians will not likely prescribe statins for lung remodeling
Analysis of: Northfield Laboratories, Inc. Reports First Quarter Fiscal 2007 Financial Results (phx.corporate-ir.net)
1. This product could very well revolutionize the delivery of oxygen to the plethora of organ systems under duress in both perioperative periods as well as in critically ill individuals.2. Decisions to delay blood transfusion for fear of transfusion reaction could probably be laid to rest as long...

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