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GLG News by Physicians who Treat Sepsis (US)

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Robert ArisNovember 18, 2008
Oral Treprostinil: An effective medicine hiding in a study with a challenging design?
Analysis of: Freedom-C Trial of Oral Treprostinil in Pulmonary Arterial Hypertension Fails to Meet Primary Endpoint | ir.unither.com
Author: Robert Aris, Associate Professor of Medicine, University of North Carolina Chapel Hill - CC
This phase III study was done without the benefit of conventional drug development with Phase I and Phase II studies (which would have provided more information about the effective dose) preceding it because pharmacokinetic date from IV and SC dosing studies were used to extrapolate for the...
Robert ArisJuly 18, 2008
Mild PAH improved by early treatment with bosentan
Analysis of: Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. | www.sciencedirect.com
Author: Robert Aris, Associate Professor of Medicine, University of North Carolina Chapel Hill - CC
While functional class II (FC II) PAH patients have been included in previous clinical trials, the EARLY trial is the first study to concentrate (ie recruit exclusively) FC II PAH patients.  This is important because the definition of functional class II is that a patient has a sight...
Robert ArisJune 10, 2008
Peer reviewed literature on Ambrisentan, a selective ETRA for PAH
Analysis of: Ambrisentan for the Treatment of Pulmonary Arterial Hypertension | circ.ahajournals.org
Author: Robert Aris, Associate Professor of Medicine, University of North Carolina Chapel Hill - CC
This Circulation paper is the first peer reviewed data on the 2 pivotal Phase III trials on ambrisentan that lead the FDA to approving it for the treatment of PAH in July 2007. This paper is critically important since all new research needs to withstand the rigor of peer-review for...
May 7, 2008
Comments on Novartis Menveo vaccine
Analysis of: Novartis Menveo® vaccine shows superior immune response against four types of meningitis disease in pivotal phase III trial | www.novartis.com
Author: GLG Expert Contributor
An encouraging development, however since the vaccine does not cover group B meningococcal disease, vigilance will be required among vaccinated individuals to insure that symptomatic individuals are not infected with group B meningococci.  The human bactericidal antibody response is considered...
January 31, 2008
Sales Reps lose out in bid for Physicians' attention.
Analysis of: 19 Percent of Office-Based Physicians Refuse to See Pharmaceutical, Biotech and Medical Device Sales Reps | www.drugs.com
Author: GLG Expert Contributor
The reason that 19 percent of Physicians refuse to see Sales Reps for Pharmaceutical, Biotech or Medical devices is easy, it's all about money. Many physicians are feeling the loss of income with higher overhead and less reimbursement. To compensate for this loss of income they schedule more patients...
January 25, 2008
Preventing Bariatric Surgery Deaths
Analysis of: Pinning Down Mortality Rates After Bariatric Surgery | www.medscape.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
 Bariatric surgery is a major operative procedure that caries significant morbidity and mortality risks due to the comorbid diseases seen in this patient population.  This procedure is increasing in frequency as more patients are willing to have it and more surgeons are becoming proficient. The...
October 8, 2007
Use of injectable zileuton may not be a panacea for asthma
Analysis of: Critical Therapeutics Initiates Phase II Clinical Trial for Zileuton Injection | www.pipelinereview.com
Author: GLG Expert Contributor
Several questions arise about injectable Zileuton.  Inhaled steroids still remain the mainstay of theray for asthma.  Will patients accept the use of an injectable drug for asthma - if it results in infrequent dosing, it may be an acceptable option for patients.  Liver function tests...
October 4, 2007
This Could Be A Real Blockbuster
Analysis of: An Old Antibiotic Could Reduce Stroke Damage | blogs.wsj.com
Author: GLG Expert Contributor
- current therapy is ineffective for most stroke victims - this study showed significant improvement in patients given   minocycline with 24 hours of stroke - if larger studies confirm this, minocycline will become the   standard of care
October 4, 2007
Finally! Rationality Returns To Psychiatric Treatment
Analysis of: Dual Approach Aids Depression Treatment | online.wsj.com
Author: GLG Expert Contributor
- this study found that a combination of antidepressant medication   and psychotherapy worked better than either treatment alone   in depressed adolescents - psychotherapy has almost disappeared in recent decades, in large   part due to low or no reimbursement by health insurance com...
October 4, 2007
Screening is a Waste of Time and Money Unless There is Treatment
Analysis of: Screening: Testing Early for Cholesterol | www.nytimes.com
Author: GLG Expert Contributor
- study from BMJ suggests screening 15 month old toddlers for   hypercholesterolemia - the problem is, there is no treatment for 15 month old toddlers with   hypercholesterolemia

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