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GLG News by Physicians who Treat Peripheral Vascular Disease

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Marc HametAugust 21, 2008
Its all about the spin
Analysis of: Heart Stents No Better Than Drugs for Chest Pain Over Time | www.bloomberg.com
Author: Marc Hamet, President, Image Guided Therapeutics, LLC.
This article could easily be spun as a victory for stent efficacy.
July 11, 2008
How to identify individuals likely to benefit from the use of Statins.
Analysis of: 8-Year-Olds on Statins? A New Plan Quickly Bites Back | www.nytimes.com
Author: GLG Expert Contributor
Widespread use of statins is likely to reduce the incidence of heart attacks and strokes and reduce the process responsible: atherosclerosis. Statins are expensive and selection of individuals and children at high to moderate risk should go beyond risk stratification by standard means and...
May 27, 2008
Thrombus Aspiration in Acute MI
Analysis of: Medtronic Says Thrombus Aspiration Before Stenting Betters Survival Rates Of Myocardial Infarction Patients | www.rttnews.com
Author: GLG Expert Contributor
Mechanical thrombectomy of the coronary arteries has becoming increasingly more common with the advent of simpler aspiration catheters.  Although its use in the setting of acute myocardial infarction is even more common, it is not routine.  Randomized data indicating its effect on clinical...
May 27, 2008
Tekturan losers blood pressure and proteinuria simultaneously
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: Jack Rubin, Medical Director, Davita Los Angeles Dialysis Center
While no more would argue that control of systolic hypertension is crucial to preventing the consequences of hypertension such as congestive heart failure, MI's, left ventricular hyperthrophy, stroke and kidney failure there are other factors that are associated with these disease states. One of these...
May 27, 2008
Promising results for tekturna
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
Novartis was able to show that combining tekturna with HCTZ provided significant improvement in blood pressure and did so safely.  They also showed that it provides better 24 hour coverage and coverage if patients miss a dose or take it late, this is a significant improvement over its competitors...
May 19, 2008
Obvious answer - wrong question - NO IMPACT on prescribing
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
It is well known that the addition of thiazide diuretic to ACEI or ARB treatment adds about 10 mm Hg reduction on top of the 10 mm Hg reduction provided by the ACEI or ARB agent.  It is expected that blocking renin in the renin angiotensin system with Tekturna would provide a similar result.
February 4, 2008
Understanding the effects of statins in low risk patients.
Analysis of: Great Drug, but Does It Prolong Life? | www.nytimes.com
Author: GLG Expert Contributor
Statin therapy in lower risk populations will not have as profound an effect as in high risk subsets but still very likely has overall positive benefits.
January 25, 2008
Preventing Bariatric Surgery Deaths
Analysis of: Pinning Down Mortality Rates After Bariatric Surgery | www.medscape.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
 Bariatric surgery is a major operative procedure that caries significant morbidity and mortality risks due to the comorbid diseases seen in this patient population.  This procedure is increasing in frequency as more patients are willing to have it and more surgeons are becoming proficient. The...
January 25, 2008
Questions about bleeding, proper dose and appropriate patient subsets will limit use
Analysis of: Daiichi Sankyo, Lilly Submit New Drug Application for Investigational Antiplatelet Drug, Prasugrel, with U.S. Food and Drug Administration | www.pipelinereview.com
Author: GLG Expert Contributor
TRITON-TIMI 38 study of 13,608 patients with ACS compared prasugrel against clopidogrel, combined with aspirin.  Prasugrel reduced the combined rate of CV death, MI or stroke (12.1% for clopidogrel vs. 9.9% for prasugrel). The benefit came at a cost of increased serious bleeding (1.4%, vs....
January 18, 2008
Outsourcing of compassionate use of drugs?
Analysis of: No right to experimental drugs for dying patients: Supreme Court | news.yahoo.com
Author: Dan Streja, Clinical Professor of Medicine, University of California, Los Angeles
The Supreme Court has rejected the use of experimental drugs by the dying patients on the grounds that "The framers (of the US constitution) understood that the pursuit of life is an inalienable right that should not be abridged without due process of law." Over the years our patients with terminal...

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