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GLG News by Physicians who Treat Insomnia (US)

David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Taro Receives Final FDA Approval For RX Cetirizine Hydrochloride Syrup ANDA (www.medicalnewstoday.com)
Here comes a prescription version of generic Zyrtec syrup.  At first glance, we wonder how it will compete with over the counter Zyrtec.  But wait...there may be a market for this drug    
Louis Sanfilippo, MD, President
Louis Sanfilippo, MD, President
LCS Group, LLC
Analysis of: Interim report for the first quarter of 2008 - strong growth in sales and profits (www.lundbeck.com)
Lundbeck has now disclosed the mechanism of action of its “mixed serotonin modulator and stimulator,” albeit buried in a first quarter report.   Data on LuAA21004, Lundbeck’s lead antidepressant jointly in development with Takeda, was released at the Scandinavian College of Neuro-Psychopharmacology...
June 23, 2008
EMRS
Analysis of: Most Doctors Aren’t Using Electronic Health Records (www.nytimes.com)
mY 6 PERSON GROUP HAS INSTALLED AN EXPENSIVE EMR ABOUT 6 MONTHS AGO . WHILE IT HAS BENEFITED US IN MANY WAYS (BETTER RECORD KEEPING FOR EXAMPLE) IT HAS BEEN VERY EXPENSVE TO INSTALL AND IMPLEMENT (HAVING TO HIRE A TECH GUY TO HELP US WT SERVER CRASHES , ETC THAT OCCUR WEEKLY).  IN ADDITION THE...
Analysis of: Clinical study shows liraglutide provides statistically significantly better blood glucose control than exenatide (www.pipelinereview.com)
A direct comparison between liraglutide and exenatide is the best way to show liraglutide's true benefit as a GLP-1 analogue. Novo Nordisk did just that and the results bode well for liraglutide. Once daily liraglutide will soon replace exenatide, given its equivalent efficacy in reducing HbA1c and...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Investigational Anti-IgE Antibody Promising as Extracorporeal Allergy Therapy (www.medscape.com)
This drug seems much more effective at reducing free-IgE levels than is Xolair.  Overall, Xolair has given many patients a tremendous improvement in their quality of life, but it hasn't fulfilled many of its promises. Frankly, some of Xolair's benefits are disappointing, particularly in the 40...
June 16, 2008
exenatide
Analysis of: After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008 (newsroom.lilly.com)
Once a week treatment for diabetes with no weight gain.
June 16, 2008
mab12
Analysis of: Investigational Anti-IgE Antibody Promising as Extracorporeal Allergy Therapy (www.medscape.com)
more prescribing habits of a more potent antibody. It also would be preferred for those patients whose IgE levels are too great fro treatment with Xolair.
Analysis of: Acomplia (rimonabant) significantly improved glucose control in type 2 diabetes patients treated with insulin (www.pipelinereview.com)
Calling a 0.89% improvement "significant" just seems to me to show the weakness of this current trial.  Anyone can use statistics to prove just about anything.  Using verbal manipulation to puff up a study's result is unfair, unreliable and just plain sad.
Analysis of: Researchers Fail to Reveal Full Drug Pay (www.nytimes.com)
When the new administration come in, medicine and big pharma are both going to be hit hard.  Industry sponsored research is going to be examined with a fine tooth comb.  All we need is another scandal.  It's getting harder and harder to trust industry sponsored research, with news coming...
Robert Aris, MD, Associate Professor of Medicine
Robert Aris, MD, Associate Professor of Medicine
University of North Carolina Chapel Hill - CC
Analysis of: Ambrisentan for the Treatment of Pulmonary Arterial Hypertension (circ.ahajournals.org)
This Circulation paper is the first peer reviewed data on the 2 pivotal Phase III trials on ambrisentan that lead the FDA to approving it for the treatment of PAH in July 2007. This paper is critically important since all new research needs to withstand the rigor of peer-review for...

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