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GLG News by Physicians who Treat Hypertension (US)

Analysis of: AstraZeneca and Bristol-Myers Squibb Submit New Drug Application in the United States and Marketing Authorisation Application in Europe for ONGLYZA™ (Saxagliptin) for the Treatment of Type 2 Diabetes (www.astrazeneca.com)
DDP4 inhibitor class fairly new.  Another arrow in the theraputic quiver
Analysis of: Drugs to Build Bones May Weaken Them (www.nytimes.com)
Patients may ask about this.  Haven't heard anyone yet.
Analysis of: Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Total Knee Arthroplasty (content.nejm.org)
The major impact of this article is that if a strategy of longer term prophylaxis is employed (6 weeks vs in hospital) that better outcomes will be seen in DVT prevention after TKA and THR.  While the drugs work differently, the difference in duration of treatment likely explains all of the difference...
July 7, 2008
Complicated issue
Analysis of: Doctors Say Medication Is Overused in Dementia (www.nytimes.com)
Many times, nursing homes will call doctors practically demanding some sort of medicne for delusional or combative patients.  They will even suggest medicines by name.  Often, these phone calls occur at 3:00 AM, and the doctor gives a quick yes to give them an answer and get back to sleep....
Analysis of: FDA Panel To Weigh Heart Trials For Diabetes Meds (www.pharmalot.com)
“A requirement for demonstrating cardiovascular benefit will likely have major implications on the availability of new treatments for type 2 diabetes, because conclusive evidence of a reduced risk of macrovascular complications in type 2 diabetes has not yet been established for any of the currently...
Carlos Dujovne, MD, Professor of Medicine and Director
Carlos Dujovne, MD, Professor of Medicine and Director
OREGON HEALTH & SCIENCE UNIVERSITY - CC
Analysis of: After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008 (newsroom.lilly.com)
More than 50% of patients have the 3 ccomponents to qualify for diagnosis of Metabolic Syndrome.Twwo of the components,Diabetes and Obesity are present in 20-25% of them and are difficult to control.Exenatide seems to provide that benefit.
Analysis of: Study Finds Chinese Food Good For Your Heart (www.medicalnewstoday.com)
Once again we are finding that traditional Chinese medicine is just as affective in this day and time as it was back during the Tang Dynasty.  Even then, Chinese red yeast rice was known to 'remove blockages' and aid in digestion.  What is even more exciting in this study,...
Analysis of: Most Doctors Aren’t Using Electronic Health Records (www.nytimes.com)
Third party payers benefit the most from EHRs because it makes charts easier to audit   The cost of implementing an EHR is excessive for a small practice of 2-5 physicians.
Analysis of: Higher Risk of Death and Stroke in Patients Given Beta Blockers After Non-Cardiac Surgery (POISE Trial) (pharmalive.com)
1.  Beta Blockers are now implicated in negative outcomes for some non-cardiac surgical patients. 2.  The POISE Trial is probably teaching us that vasoactive medications need to be utilized judiciously, given to many, but not all surgical patients. 3.  The POISE Trial results conflict...
Analysis of: AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six (www.pipelinereview.com)
Good drug with rapid onset.  ? if will create some confusion with adult dosing    

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