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GLG News by Physicians who Treat Graft-versus-Host disease

Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Introducing Abstral(R). Innovative Drug Delivery Technology For Rapid Breakthrough Cancer Pain Management (www.medicalnewstoday.com)
Always room for more pain medications/formulations for cancer patients The sublingual fentanyl approach is a highly desirable formulation due to rapid onset of action ie BTP control The concern is the faster they can be made to act, the more the abuse potential by non cancer patients
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients (www.washingtonpost.com)
Higher doses of conventional chemotherapy agent , improves outcome in AML A large population of  AML patients are elderly The "higher the dose of chemo, the better" concept still applies to some malignancies
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Scientists recommend 'black box' for Avastin (www.fiercepharma.com)
Satistics are usually used to reveal dramatic differences Patients often misinterpret relative differences for absolute ones patients are willing to do a lot more to get any benefit in cancer outcome
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Merck KGaA: Overall Survival in First-Line NSCLC Reaches 15 Months (www.drugs.com)
Many studies support EGFR response correlates with rash Many attempts to actually increase the incidence of rash Most patients will use the EGFR treatments despite the rash
Robert Aris, MD, Associate Professor of Medicine
Robert Aris, MD, Associate Professor of Medicine
University of North Carolina Chapel Hill - CC
Analysis of: Freedom-C Trial of Oral Treprostinil in Pulmonary Arterial Hypertension Fails to Meet Primary Endpoint (ir.unither.com)
This phase III study was done without the benefit of conventional drug development with Phase I and Phase II studies (which would have provided more information about the effective dose) preceding it because pharmacokinetic date from IV and SC dosing studies were used to extrapolate for the...
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Tarceva successful as maintenance therapy (www.fiercebiotech.com)
Saturn trial attempted to focus on EGFR reative patients Saturn was positive as a maintenance therapy, while concurrent was not
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Phase II Trial of Sorafenib in Advanced Thyroid Cancer (jco.ascopubs.org)
TKI's have been establihed in a small number of refractory solid cancers With slow migration to other venues, we are seeing new applications
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer (pharmalive.com)
Recent Cell Genesys vaccine trial for prostate cancer fails The trial not only shows lack of efficacy, but possible harm from the vaccine arm of the trial
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Targeting EGFR in Colorectal Cancer (content.nejm.org)
We are facing an ever increasing expense of treating cancver The so called targeted drugs are the big price items The recent discovery of theses drugs have sometimes been out of order with understanding their activity
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer (pharmalive.com)
Be cautious of vaccine approaches to cancer No cancer has had success with the use of vaccine therapy We are far from figuring out the reason for failure of vaccines to treat cancer

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