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GLG News by Physicians who Treat GERD (US)

Analysis of: Drinkers With The Alcohol Dehydrogenase 1C*1 Gene Are At Greater Risk Of Colorectal Cancer (www.medicalnewstoday.com)
High blood acetaldehyde levels are associated with more liver and perhaps pancreatic damage and inflammation thus enhancing neoplasia. How would high blood acetaldehyde levels induce colorectal cancer? Also through inflammation. The alcohol dehydrogenase polymorphism is common in Asians yet there is...
Analysis of: Rosetta Genomics Announces Commercial Availability of Its Third MicroRNA-Based Diagnostic Test: miRview(TM) meso (phx.corporate-ir.net)
Previous 'simple' molecular tests for cancer have ussually not worked out in practice. Although microRNA's have cellular control function for multiple genes it is premature to believe that these tests will be more successful.
Analysis of: FDA Faults Wrinkle Fillers Over Warnings (online.wsj.com)
Dermal Fillers are a popular and growing procedure that is poorly regulated.  Although problems arise in their administration, it is not clear whether it is due to the product or user technique.  That key difference is essential to quantify before issuing warnings
Carlos Dujovne, MD, Professor of Medicine and Director
Carlos Dujovne, MD, Professor of Medicine and Director
OREGON HEALTH & SCIENCE UNIVERSITY - CC
Analysis of: CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin Outcomes Study (www.astrazeneca.com)
1:Crestor is the most potent statin in the market,yet is 3d in sales behind Zocor and Lipitor.2:The efficacy supriority together with its capacity to lower CRP levels led to the highest rate of ASCVD prevention in the shortest period of time evr documented in statin trials.3:The trial in near 18,000...
Analysis of: Task force: Colon cancer screenings can stop at 75 (news.yahoo.com)
The best epidemiologic data states that the incidence of colorectal cancer as well as most other cancers falls drammatically after age 85. Thus screening for a dissappearing disease makes no sense. Also colorectal cancer takes an average of 8-10 years to develop so that screening for average risk individuals...
Carlos Dujovne, MD, Professor of Medicine and Director
Carlos Dujovne, MD, Professor of Medicine and Director
OREGON HEALTH & SCIENCE UNIVERSITY - CC
Analysis of: Many Trial Reports on FDA-Approved Drugs Go Unpublished (www.washingtonpost.com)
This article is not news for clinical researchers like myself that have performed hundreds of clinical trials in collaboration with the Pharmaceutical Industry. Some of the most common reasons for that are: A)Negative studies are difficult to get published.B)Negative results for the dug of the...
Analysis of: Stark Offers Bill to Hasten e-record Adoption (modernhealthcare.com)
The Stark bill aims to offer both incentives and eventually financial penalties to speed the adoption of electronic medical records. It includes provisions that would create a "standard", however it is unclear the degree of interoperability different systems would have, and the degree to which the interfaces...
Analysis of: As Doctors Cater to Looks, Skin Patients Wait (www.nytimes.com)
With excellent patient satisfaction, ease of use and excellent cash based reimbursement, there is a rapidly growing aesthetic & skin care business to dermatologic practice.  This has clearly impacted access to care by patients with skin disease in my area.  Perhaps a better question is...
Analysis of: Why anaesthetics can make the pain worse (www.newscientist.com)
Pain is a complex of the personal, subjective, and unpleasant experiences  that may or may  not be related to physical injury or tissue damage.  It has been described “timeless, ineluctable, and disconcertingly indefinable.”  The expression may be influenced by psychosocial, ...
Carlos Dujovne, MD, Professor of Medicine and Director
Carlos Dujovne, MD, Professor of Medicine and Director
OREGON HEALTH & SCIENCE UNIVERSITY - CC
Analysis of: After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008 (newsroom.lilly.com)
More than 50% of patients have the 3 ccomponents to qualify for diagnosis of Metabolic Syndrome.Twwo of the components,Diabetes and Obesity are present in 20-25% of them and are difficult to control.Exenatide seems to provide that benefit.

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