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GLG News by Physicians who Treat End Stage Renal Disease (ESRD)

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November 19, 2008
Plavix and Nexium: incomplete data wrongly interpreted.
Analysis of: Plavix Study Faults Mixing Pills | online.wsj.com
Author: GLG Expert Contributor
Heartburn and heart attack are two types of discomfort in the chest. Patients with coronary artery disease AND gastro-esophageal reflux disease often take PPI for chest pain and, therefore, tend to seek medical attention in more advanced stages of coronary artery disease.
October 20, 2008
Stent Oligopoly: bigger stakes, bigger trials.
Analysis of: Health Firms to Study Clots in Stent Patients | online.wsj.com
Author: GLG Expert Contributor
This collaboration will be very successful: the trial involving 20 000 patients will take a long time to complete. During the trial utilization of stents will not change. Upon completion of the trial it will become even more obvious that 2 years of "blood thinning" is better than 1 year for stents potency...
October 20, 2008
Amiodarone is here to stay.
Analysis of: Wyeth Heart Drug Not A Short-Term Option | www.pharmalot.com
Author: GLG Expert Contributor
Amiodarone is still one of the best drugs for atrial fibrillation despite "rare incidence" of cirrhosis, lung fibrosis and now "rare muscle injury".
October 20, 2008
Medtronic: chasing the tail.
Analysis of: Medtronic Endeavor Heart Stent Tied to Complications | www.bloomberg.com
Author: GLG Expert Contributor
Utilization of a device in a setting of marginal data is not driven by that data, but by the reimbursement rates. Medtronc might loose the battle, but stents are still winning the war.
October 14, 2008
End of Era: Abbott's Attempt.
Analysis of: Abbott: Clinical trial shows stent 'does its job' | www.forbes.com
Author: GLG Expert Contributor
Currently, bioabsorbable stents do not provide better solution than traditional stents for the major problems of early thrombosis and absence of long term advantage compared with medical management (in appropriate patients).
October 14, 2008
Great Relieve: not Stroke, only Death and Heart Attack.
Analysis of: Data show no stroke risk with Pfizer lung drug: FDA | www.reuters.com
Author: GLG Expert Contributor
The risks of death and myocardial ischemia have not been disproved. The data of stroke possibility was not finalized by FDA.
October 13, 2008
Misleading Headline
Analysis of: C. Difficile And Antibiotics Not Necessarily Linked, Study Finds | www.sciencedaily.com
Author: GLG Expert Contributor
The headline is misleading. C. Dif. diarrhea is well established consequence of antibiotics induced imbalance in the colon. The cited study did not disprove that. What the study actually showed that C. Dif. diarrhea can be also induced by other, unknown so far, factors as well as by antibiotics.
October 13, 2008
Disease-risk Data: will be read, but will not be implemented.
Analysis of: Study to Track How People React to Disease-Risk Data | online.wsj.com
Author: GLG Expert Contributor
The data obtained from genetic analysis will be more of inherited predisposition to certain conditions type rather than cause-sequence relationship type. Therefore, it can be compared to other analyzes of risk factors such as credit score or car insurance assessment. It will be, therefore, read, appreciated and...
October 6, 2008
Risky of Safe: can be both depending on patient selection (just like all other drugs).
Analysis of: COPD Medicines: Risky or Safe? | www.webmd.com
Author: GLG Expert Contributor
Of course anticholinergic drugs leave sympathetic stimulation unbalanced. They, therefore, may act in certain individuals as weak sympathomimetic producing arrhythmias, hypertension, tachycardia, vasoconstriction etc. with know sequences, such as atherosclerosis, cerebrovascular and coronary effects....
October 6, 2008
Killer gas from basement is a cause of lung cancer.
Analysis of: Protecting a Home From Silent Threat | www.nytimes.com
Author: GLG Expert Contributor
How somebody can possibly come up with mentioned estimation: "...20,000 people die from radon-induced lung cancer every year..."? Where is the denominator: how many non-smokers with documented constant radon exposure acquire lung malignancy?

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