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GLG News by Physicians who Treat Depression (US)

Analysis of: ADAGIO Trial Results Show Teva's AZILECT(R) 1 Mg Tablets Slow Progression Of Parkinson's Disease (www.medicalnewstoday.com)
This large study shows that PD patients' severity of motor dysfunction is better on rasagiline than on placebo.
July 31, 2008
Be very careful
Analysis of: Blood pressure drugs may protect against Alzheimer's (www.washingtonpost.com)
All is not as it seems when reported in the press, especially the non-scientific press.
Analysis of: TheraGenetics Licenses Intellectual Property Related To Predicting Patient Response To Antidepressant Therapy (www.medicalnewstoday.com)
-Pharmacogenetic tests have not made it into the treatment or assessment process for most physicians. -Until the cost for these tests become negligible -- or, included in the cost of a particular antidepressant -- psychopharmacogenetic testing will not make it into the mainstream. 
Louis Sanfilippo, MD, President
Louis Sanfilippo, MD, President
LCS Group, LLC
Analysis of: TheraGenetics Licenses Intellectual Property Related To Predicting Patient Response To Antidepressant Therapy (www.medicalnewstoday.com)
“Personalized medical diagnositics” looks to be evolving as a high impact area in neuropsychiatric drug development.  Such ‘genetic biomarker’ platforms, based on either pharmacogenetic profiles coming from DNA blueprints or gene products from a simple blood draw, aim to identify patients who are...
Analysis of: 8-Year-Olds on Statins? A New Plan Quickly Bites Back (www.nytimes.com)
We do not know enough about the effects of statins over a lifetime to justify use in children. Maybe we would reduce cardiovascular mortality, maybe not.  But at what cost?  I'm talking about both financial costs and the health costs related to drug side effects.  We need a lot more information...
Louis Sanfilippo, MD, President
Louis Sanfilippo, MD, President
LCS Group, LLC
Analysis of: One drug, many uses. Good idea? (www.indystar.com)
‘One drug, many uses’ can make lots of sense clinically and commercially.   Seeking additional FDA indications for a specific drug has obvious business benefits:  greater revenue stream, improved branding, potentially longer market exclusivity, greater franchising potential of the drug...
Analysis of: Why anaesthetics can make the pain worse (www.newscientist.com)
Pain is a complex of the personal, subjective, and unpleasant experiences  that may or may  not be related to physical injury or tissue damage.  It has been described “timeless, ineluctable, and disconcertingly indefinable.”  The expression may be influenced by psychosocial, ...
Louis Sanfilippo, MD, President
Louis Sanfilippo, MD, President
LCS Group, LLC
Analysis of: Interim report for the first quarter of 2008 - strong growth in sales and profits (www.lundbeck.com)
Lundbeck has now disclosed the mechanism of action of its “mixed serotonin modulator and stimulator,” albeit buried in a first quarter report.   Data on LuAA21004, Lundbeck’s lead antidepressant jointly in development with Takeda, was released at the Scandinavian College of Neuro-Psychopharmacology...
Analysis of: Doctors Say Medication Is Overused in Dementia (www.nytimes.com)
We need to look to the cause of why we prescribe antipsychotics to patients with dementia.  We have very few tools to use and sometimes these drugs are a necessity.
Analysis of: Doctors Say Medication Is Overused in Dementia (www.nytimes.com)
Medications used for realistic indications and with clinically appropriate symptomatic targets are indicated and provide effectiveness that additional staff cannot offer.  Decision making in health care is too often made by those who do not really provide clinical service but provide arm chair...

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