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GLG News by Physicians who Treat Acne (US)

March 12, 2007
New agent for PHN
Analysis of: Depomed Completes Patient Enrollment in Phase 3 Clinical Trial of Gabapentin GR in Postherpetic Neuralgia (www.redorbit.com)
The treatment of PHN is sometimes quite difficult, so new formulations of old agents are always an exciting development.Gabapentin immediate release is a first-line option for the treatment of PHN, but dose escalation is limited by its dose-related fatigue.Extended-release gabapentin makes sense, as...
Analysis of: US aims to break drug industry's hold on pricing (www.newscientist.com)
For difficult to control hypertensive patients, newly approved drugs provide a level of excitement that blood pressure targets can finally be reached.Renin inhibitors, when used in combination with more established classes of antihypertensives, will hopefully help many get to goal, but will the side...
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: Allegiance Equity Corporation Announces Positive Results of In Vitro Studies and an Open Label Trial for Relieva(R) in Treating Atopic Dermatitis (www.pipelinereview.com)
The open label trial results for the product Relieva from Allegiance Equity Corp. are encouraging. However the trials need to be double blinded, and with a much larger number of patients. If the product can be compared to a low- mid potency topical steroid in efficacy, then it will be successful. Homeopathic...
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: Basilea Reports Positive Phase III Results for Alitretinoin (www.pipelinereview.com)
This large phase 3 trial for Alitretinoin results are significant in the this would be the first oral agent specifically for resistant hand dermatitis. the results are positive with good significance. The major problem will be getting the FDA  to accept the drug without the onerous pregnancy prevention...
Gregory Buford, MD, Plastic Surgeon and Medical Director
Gregory Buford, MD, Plastic Surgeon and Medical Director
BEAUTY by BUFORD
Analysis of: Silicone Breast Implants Face Hearings in Congress (www.alternet.org)
There is continued controversy regarding silicone breast implants despite substantial scientific proof that they are a safe long-term option.There are several implications made in this article that are grossly incorrect.
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: Excessive Use of Topical Anesthetics Can Be Fatal (www.medscape.com)
Compounded topical anesthetics can have dangerous side effects if used inappropriately over large surface areas, large amounts, under occlusion, for long periods, etc. Rational, supervised use is safe and very helpful in controlling pain in many outpatient laser and other procedures
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: No Need to Switch Retinoids During Acne Vulgaris Treatment (www.medscape.com)
This poster at the 2007 American Academy of Dermatology meeting in Washington, DC indicates that Galderma's product, Adapalene, is as effective as Allergan's product Tazarotene. This is opposite to 2 other studies that have been done in the past indicating that Tazarotene is the most effective retinoid,...
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: Obagi Medical Products, Inc. Launches CLENZIderm M.D. Penetrating Acne Therapeutic System (www.pharmalive.com)
Obagi Medical Products Clenziderm should have a positive impact:1. It allows the physician or the medical aesthetician under the physician’s guidance to dispense an effective product without a prescription.2. Its efficacy may approach that of prescription products, and studies are needed to confirm...
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: Ceragenix Completes Patient Visits for EpiCeram Clinical Study (www.pharmalive.com)
Ceragenix's new product Epiceram, the Barrier repair cream has potential merit and efficacy comparable to mid strength topical steroids:1. Barrier repair has been found to be antiinflammatory.2. The product in mouse studies has effects comparable to steroid creams.3. The product will have less/ minimal...
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Sunil Dhawan, MD, Clinical Assistant Professor of Dermatology
Stanford University
Analysis of: Centocor, Inc. Releases Phase 2 Data on Novel Biologic CNTO 1275 Targeting Chronic Plaque Psoriasis (pharmalive.com)
Centocor's product CNTO1275 will have a major and sustained impact on the market:1. Its PASI 75 reduction is better than the current injectables other than Centocor's Infliximab, which requires a complicated IV infusion.2. Side effects are comparable to other agents.3. It is specifically being developed...

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