Analysis of:
MacroGenics and JDRF Sealed Partnership to Support Pivotal Phase II/III Clinical Trial of Anti-CD3 Monoclonal Antibody for Children and Adults with Recent-Onset Type 1 Diabetes (www.pharmagazette.com)
Anti-CD3 antibodies such as teplizumab (MGA031, hOKT3-gamma-1 (Ala-Ala)) are engineered to block the function of CD3 cells, immune T cells that orchestrate the destruction of islets. This prevents "activation" of the T cells after they have identified their target, disarming them once they are poised...
Analysis of:
Men, Boys Lack Options to Treat Eating Disorders (online.wsj.com)
If one takes the perspective that eating too little and eating too much are simply different sides of the same coin, the female limited focus on anorexia nervosa does not make much sense. Surely men and women are different, but using food or restricting food to meet emotional needs is pretty common...
Analysis of:
Caraco Pharmaceutical Laboratories Ltd. Announces FDA Approval To Market Generic Ambien(R) (www.medicalnewstoday.com)
Zolpidem is very widely used and the generic should have a substantial market.
Analysis of:
Health Effects Of Casinos Have Been Ignored, Say Experts (medicalnewstoday.com)
Pathological gambling rates vary to some degree with the availability of opportunies to gamble. Gambling venues provide tremendous profits to both the casino industry and the governments who tax their revenues.
Analysis of:
Bariatric surgery - possible treatment for type 2 diabetes mellitus (www.news-medical.net)
There is reasonably good data emerging that bariatric surgery can be effective in treating obesity related complications. However, as the prevalence of bariatric surgery increases in the U.S. in an exponential manner, there are many patients who have received this surgery without us knowing the...
Analysis of:
Is Your Favourite Red Wine Really That Good For You? (www.medicalnewstoday.com)
The data on benefits of antioxidants in wine are sufficiently tenuous that I would not build an edifice on measuring resveratrol in favorite wines to determine which wine to choose to drink.
Analysis of:
Trial Information: A Phase III, Double-Blind, Placebo-Controlled safety and efficacy trial of Flibanserin 25mg/twice a day and 50mg/once and twice dai (www.centerwatch.com)
The relationship between sexual drive and depression is one of the great unexplained enigmas. It is, in my opinion, no coincidence that many of the antidepressants currently on the market have as a side effect reduced libido (sex drive). Moreover, it is interesting that improvement of mood...
Analysis of:
CIGNA Behavioral Health Program Reduces Overall Health Care Costs and Improves Patient Outcomes (www.prnewswire.com)
That clinical case management improves outcome and reduces costs is nothing new. What is new is that this service is provided by the insurance company. What is not clear is what this insurance provided service actually costs and does.
Analysis of:
Triple Reuptake Inhibitors: What to Expect from “Mega-Andipressants” (www.currentpsychiatry.com)
I am getting tired of the monoamine hypothesis of depression. This "tripple threat" neurotransmitter reuptake inhibitor sounds to me like just the latest version of a long and rather exhausting story. The future for antidepressants lies in getting beyond the monoamines.
Analysis of:
Dark Chocolate May Lower Risk Of Cardiovascular Disease (www.medicalnewstoday.com)
Dark chocolate contains antioxidants which may improve endothelial functioning. Endothelial dysfunction has been implicated in cardiovascular complications of smoking, hyptertension, diabetes, angina, coronary artery disease, etc.