Analysis of:
Painkiller Widely Abused in South (www.washingtonpost.com)
Painkillers are not the problem; the problem is the people who prescribe them and those who take them. The biggest problem is that the medical profession was encouraged (look at the old advertisements if you have the time) to prescribe slow-release oral formulations of opioids for CHRONIC...
Analysis of:
Wyeth's Schizophrenia Pill Is Rejected by U.S. FDA (www.bloomberg.com)
Although the atypical antipsychotics are developed for the treatment of psychosis, in reality they are now most often used as adjunctive treatments to antidepressants and mood stabilizers, for control of anxiety, for enhancing sleep, and in treatment of personality disorders that involve behavioral...
Analysis of:
Crystal-Clear Exercise Advice From U.S. Heart, Sports Medicine Groups (www.webmd.com)
This is a very clear and succinct pronouncement from two august organizations. There is little room for misinterpretation. However, clear pronouncements do not a change in behavior make.
Analysis of:
Successful Proof-of-Concept With Actelion's Orexin Receptor Antagonist in Patients Suffering From Primary Insomnia -- First Demonstration of Key Role of Orexin System in Humans Suffering From Sleep Disorders (www.primenewswire.com)
Physiologically-based management of primary insomnia is a step in the right direction, as is the advent of new sleep medications that address other than the GABA system. Development of these medications follow the strategy of modulating a brain orexin neurons with Orexin-OX1/OX2 receptor...
Analysis of:
The Unmedicated Mind: Backlash against antidepressants is fueling new interest in alternative treatments (online.wsj.com)
The backlash against antidepressants is not a bad thing if depression is addressed in other ways that work. Doubtless such a backlash will reduce antidepressant drug sales, but it will lead to exciting opportunities in health maintenance and holistic medicine. The bottom line--depression...
Analysis of:
UK Regulator: 1 Person in 10 on Acomplia Experiences Psychiatric Side Effects (www.acompliareport.com)
Patients with obesity are the predominant target of rimonobant therapy in the U.K. Patients with obesity are at significantly increased risk for psychopathology, including depression.
Analysis of:
ABILIFY(R) (aripiprazole) Supplemental New Drug Application Receives Priority Review by U.S. Food And Drug Administration for Adjunctive Treatment in Adults With Major Depressive Disorder (www.pipelinereview.com)
Aripiprazole is before the FDA with priority status and will (probably) be approved for an adjunctive role in treatment of major depressive disorder. Add to that its approved use in bipolar disorder and its frequent use in anxiety, it still does not have much to offer that its competition risperidone,...
Analysis of:
J&J Hasn't Given Up on Sex Pill for Men (www.forbes.com)
With medications like this medical necessity and lifestyle improvement are becoming increasingly blurred. People will pay handsomely to improve their sexual satisfaction. Moreover, companies who cater to these needs stand to make incredible profits. This is a "free country" and people...
Analysis of:
Adolor Corporation Initiates First of Three Proof of Concept Studies of Novel Delta Opioid Agonist for the Management of Pain (www.pipelinereview.com)
A series of compounds were prepared by Adolor which have significant affinity for the delta opioid receptor and presumably not the mu or kappa receptors. Since the latter two receptors are predominantly responsible for toxicity associated with opioid drugs, the notion is that ADL5859 will have...
Analysis of:
Pediatric SSRI Use, Depression Diagnosis Dropped After FDA Advisory (www.medscape.com)
Why should the rate of pediatric depression decrease just because the FDA has issued a black box warning about the use of SSRIs in children and young adults? Nevertheless, this was the finding of a recent article in the Journal of the American Psychiatric Association.