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GLG News by Physicians who Prescribe Opioids

December 16, 2008
Remember the frying pan?
Analysis of: Scientists back brain drugs for healthy people (www.washingtonpost.com)
This is an abuse of medication - what we don't need
December 15, 2008
Asthma - will this help??
Analysis of: FDA: Long-Acting Asthma Drugs Increase Asthma Risks (online.wsj.com)
Ruling not unreasonable, but may cause confusion to patients.
John Hsu, MD, Director of Anesthesiology
Presbyterian Intercommunity Hospital Inc
Analysis of: Survey: Hospital EHR Adoption Rate is Below 12% (www.govhealthit.com)
The lack of a comprehensive EHR implementation suggests that we are failing at our goal of improving the healthcare system.  While the article highlights many problems, very few solutions are offered to remedy this part of our healthcare crises. The key implications are: 1....
Analysis of: Study Published In Archives Of Surgery Demonstrated Benefit Of Entereg (Alvimopan) In Postoperative Ileus (pharmalive.com)
Alvimopan given 30 to 90 minutes before surgery showed similar benefit as when given more than 2 hours pre-operatively.  Since patients often don’t arrive at the hospital 2 hours before surgery, it would certainly be more convenient to administer the drug closer to the time of surgery.
Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: FDA Asks if Pain Pill Is Tamper-Proof (online.wsj.com)
Abuse resistant long acting narcotics offer benefit as they are less desirable to those who might wish a quick high via snorting, injecting crushed time-release narcotic. Unfortunately, given the higher cost than long acting generics and increased pressure on physicians to prescribe generics, expect...
Analysis of: Unclear how much pounding new hips, knees can take (news.yahoo.com)
Patients, especially so called "boomers" can have unrealistic expectations of appropriate activity levels after joint replacement surgery. Like an mecahnical sytem they are subject to fatigue which could lead to early failure. It is up to surgeons to set realistic expectaions for patients, al;though...
August 27, 2008
A rough in the diamond
Analysis of: FDA Alert: Hemorrhagic or Necrotizing Pancreatitis in Patients Taking Byetta (www.fda.gov)
If truly an association, this will alter the use of this drug.
Analysis of: Higher Risk of Death and Stroke in Patients Given Beta Blockers After Non-Cardiac Surgery (POISE Trial) (pharmalive.com)
1. 10% of the data was rejected because the data was "fraudulent" - ie: research centers received payment, but there was not actually a patient associated with the data points. 2. No oversight was conducted of the research locations.  A majority of research centers were in various 3rd world countries. ...
Analysis of: Drugs to Build Bones May Weaken Them (www.nytimes.com)
This should not deter the practicing physician to prescribe these agents osteoporosis will reach epidemic proportions and if we can reduce fractures by 50% the savings within the healthcare system will be enormous that's not to say that individuals albeit rare may have a propensity to develop fractures...
Analysis of: AstraZeneca and Bristol-Myers Squibb Submit New Drug Application in the United States and Marketing Authorisation Application in Europe for ONGLYZA™ (Saxagliptin) for the Treatment of Type 2 Diabetes (www.astrazeneca.com)
DDP4 inhibitor class fairly new.  Another arrow in the theraputic quiver

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