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GLG News by Physicians who Perform Procedures using MammoSite

Analysis of: Study Supports Simultaneous Technique for Breast-Conserving Radiotherapy (www.medscape.com)
Standard breast conserving therapy consists of breast conserving surgery followed by whole breast radiotherapy (to a dose of 45-50.4Gy), followed by a boost to the lumpectomy site of 10-16Gy for a total dose of 61-66Gy.    The boost is typically done after the completion of whole breast...
Analysis of: New Medicare Regulations Adopted To Reduce Certain Hospital Infections And Medical Errors (www.medicalnewstoday.com)
CMS's latests decision to not reimburse hospitals for medical errors and hospital acquired infections has been widely discussed on these newsgroups.   Simpy put, while medical errors and infections are unfortunate and can have adverse consequences, the key here is which of these events could...
Analysis of: Antisoma's ASA404 1800 mg/m2 lung cancer trial will report positive survival data (www.therapeuticsdaily.com)
ASA404 is a small-molecule vascular disrupting agent that selectively disrupts established tumour blood vessels, in theory allowing chemotherapy to reach tumor cells. The data to date in NSCLC is quite promising, with significant increases in overall and medial survival when combined with...
Analysis of: Philips SpeechMagic Used In Largest Deployment Of Front-End Radiology Speech Recognition In The UK (www.medicalnewstoday.com)
In the modern era of medicine, where documentation and communication is important, fast turn around of dictated reports (radiology, consultation, progress notes) is important for an efficient workflow. Speech recognition software has improved dramatically over the last decade, allowing for relatively...
Analysis of: Blue Shield of California to pay $31M in quality bonuses to state medical groups (www.fiercehealthcare.com)
Pay for performance is here, and being used in actual reimbursements.    This is an example of this in the private payor model.
Analysis of: Poniard Pharmaceuticals Announces Initiation of Picoplatin Phase 2 Trial in First-line Treatment of Hormone-Refractory Prostate Cancer in Combination with Docetaxel and Prednisone (money.cnn.com)
Taxotere with prednisone is the standard first line chemotherapy for hormone refractory prostate cancer based on the results of the TAX 327 trial.   The ongoing phase II trial looks to see if the addition of a platinum based agent to taxotere improves outcomes in hormone refractory prostate...
August 20, 2007
A long way to go
Analysis of: Phase I intravenous trial for anti-cancer drug achieves primary objectives (www.pipelinereview.com)
Cytopias new agent CY997 has met it's phase I goal to determine MTD and DLT - not a hard task to have done.   Either it's tolerable and safe or not tolerable and not safe.   In this case, the former holds true. However, without more significant clinical data - phase II and III -...
Analysis of: By 2008, Medicare won't pay for hospital errors (www.fiercehealthcare.com)
Well....we know CMS doesn't have enough money to fund healthcare in perpetuity.   Physicians have been taking reimbursement cuts or lack of raises over the last 5 years.    Realizing you can't squezze enough money out of the physicians, Medican now brilliantly plans to...
Analysis of: Oncoscience AG, the european partner of YM BioSciences, announces completion of patient enrollment in phase III brain cancer trial of nimotuzab (www.pipelinereview.com)
Glioblastomas and diffuse pontine gliomas in adults and children are agressive, and nearly universally fatal.  The standard of care today for GBMs is concurrent chemoradiotherapy with Temodar, based on the results of the NCIC trial (Stupp, et al., NEJM, 352:987-96, 2005).   For diffuse...
Analysis of: Spectrum Pharmaceuticals Investigational New Drug Application for SPI-1620 Cleared by U.S. Food & Drug Administration (www.pipelinereview.com)
There are many theories out there about how angiogenesis affects tumor growth.   One theory is that anti-angiogenic agents emilinate the leakiness of blood vessels, improving flow of blood and chemotherapy to the tumor, essentially getting more of a cytotoxic agent to the target. SPI-1620...

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