The Expertise Imperative and Compliance Technology
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Retrospective studies should be viewed with caution.
Most retrospective studies which may contain a bias in the prescribed treatment should be anlysed with matched propencity score.
To confirm the results a randomized trial would essentially be needed.
Generic drugs are cheaper equivalent of brand-name (aka proprietary) drugs which become available after a specific drug patent expires. There is ongoing debate whether generic drugs are as safe and as effective as their brand-name counterparts. Recent evidence from a comprehensive review published in...
The Endeavour stent appears to have a higher restenosis rate than currently marketed Drug Eluting Stents without the improved safety profile claimed by the company. This finding is at odds with the companies marketing message to cardiologists. These studies, along with the introduction of...
Metabolic syndrome is a cluster of individual characteristics that has been preliminarily associated with adverse events such as heart attack and stroke If proved an independent cause of cardiovascular disease, metabolic. syndrome could become another feasible target of pharmacologic primary prevention,...
Mechanical thrombectomy of the coronary arteries has becoming increasingly more common with the advent of simpler aspiration catheters. Although its use in the setting of acute myocardial infarction is even more common, it is not routine. Randomized data indicating its effect on clinical...
It is well known that the addition of thiazide diuretic to ACEI or ARB treatment adds about 10 mm Hg reduction on top of the 10 mm Hg reduction provided by the ACEI or ARB agent. It is expected that blocking renin in the renin angiotensin system with Tekturna would provide a similar result.
Statin therapy in lower risk populations will not have as profound an effect as in high risk subsets but still very likely has overall positive benefits.
Bariatric surgery is a major operative procedure that caries significant morbidity and mortality risks due to the comorbid diseases seen in this patient population.
This procedure is increasing in frequency as more patients are willing to have it and more surgeons are becoming proficient.
The...
TRITON-TIMI 38 study of 13,608 patients with ACS compared prasugrel against clopidogrel, combined with aspirin. Prasugrel reduced the combined rate of CV death, MI or stroke (12.1% for clopidogrel vs. 9.9% for prasugrel).
The benefit came at a cost of increased serious bleeding (1.4%, vs....
The reality that the actual details of the ENHANCE have not been circulated and that alternate explanations or caveats may be raised is probably unimportant. The bottom line carries the day and the bottom line is that the trial's title, ENHANCE, was not achieved by the addition of VYTORIN when...