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GLG News by Physicians in the U.S. who Treat Patients with Myelodysplastic Syndromes (MDS)

Analysis of: Roche Files Avastin for Wider Label in EU (www.therapeuticsdaily.com)
"The filing is supported by data from the phase III Avado trial, which investigated Avastin in combination with docetaxel compared wwith docetaxel alone in the first-line treatment of patients with metastatic breast cancer, Roche said in a statement."
Analysis of: Sorafenib in Advanced Hepatocellular Carcinoma (content.nejm.org)
Sorafenib increases time to progression and median survival in HCC. (World wide a major neoplasm)
Analysis of: Detection of Mutations in EGFR in Circulating Lung-Cancer Cells (content.nejm.org)
Peripheral blood in patients with metastatic non small cell lung cancer (NSCLCA) can determine the presence of EGFR mutations in circulating cancer cells that will reveal sensitivity to TKI's- Erbitux (ImClone & BMS), Tarceva (Genentech) and even Iressa (AZ).
Analysis of: Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non–Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy (jco.ascopubs.org)
Lung cancer patients who have increased gene copies of EGFR do better with Cetuximab than do those who do not.
Analysis of: Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer (jco.ascopubs.org)
Individualizing chemotherapy depending on histology (adenocarcinomas) shows that Alimta/CisPlatin appears to be more convenient and less toxic than its stablemate Gemzar.
Analysis of: Patients Curb Prescription Spending (online.wsj.com)
The idea that people will always buy prescription and OTC drugs and will go to the physician and dentist, no matter what the economic conditions in the country, is, in my opinion, erroneous.  People's first priorities are getting to work (requiring gas), food, and shelter.  The most money...
Analysis of: Rituximab and Intravenous Immune Globulin for Desensitization during Renal Transplantation (content.nejm.org)
For patients with antibodies that may make renal transplants problematic, Rituxan may make them possible!
Analysis of: Glaxo Seeks Guidance From Health Systems (online.wsj.com)
GSK is discussing drug development with European countries and not the US. Implications???
Analysis of: Bill to Block Medicare-Fee Cuts (online.wsj.com)
Medicare will not cut physicians fees but will cut payments in HMO driven Medicare "advantage" plans. This means that the republicans will be unable to "feather the nest" of their insurer friends!
Analysis of: Pricey Drugs Put Squeeze on Doctors (online.wsj.com)
Chemotherapy drugs are so costly that not only are the patients unable to pay co-pays, but oncologists are laying out hundreds of thousands of dollars with only a promise they will be reimbursed.

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