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GLG News by Physicians in the U.S. who Treat Chronic Obstructive Pulmonary Disease (COPD)

David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: FDA Approves XYZAL(R) (Levocetirizine Dihydrochloride) Tablets For The Relief Of Seasonal And Year Round Allergies, And Chronic Hives (www.medicalnewstoday.com)
Levoceterizine is the left-handed isomer of ceterizine (Zyrtec).  It gives all the antihistaminic effect of Zyrtec with, maybe, half the sedation.  But it ain't non-sedating!  Look at its own data:  6% sedation with Xyzal, 2% with placebo.  As such, I must respectfully disagree...
Mark Vandewalker, MD, Allergy Specialist and Partner
Allergy & Asthma Consultants Of The Ozarks Ltd
Analysis of: AstraZeneca Launches New Advance In Asthma Treatment - Symbicort Maintenance And Reliever Therapy (Symbicort SMART) (www.medicalnewstoday.com)
Symbicort is AstraZeneca's answer to Advair, presently the number one combination ICS/LABA in the U.S. for treating moderate to severe asthma. Symbicort will not, however, have an indication for quick relief of bronchospasm as it does in many European countries. Nevertheless, Symbicort appears to be...
Analysis of: Cervarix® Data Show That Higher Levels Of Antibodies In The Bloodstream Correlate To Higher Levels In Cervico-vaginal Secretions (www.medicalnewstoday.com)
Cervarix is a vaccine, not a treatment for cervical cancer. It immunizes against two of the more common strains that cause cervical cancer just like Gardasil, except Gardasil includes four viruses and Cervarix only two.
Analysis of: Asthma treatment alternatives promising (www.sun-sentinel.com)
This is more a study to support the use of salmeterol plus fluticasone (Advair) after a study a year or so ago showed an increase in deaths for asthmatics using only salmeterol. It is not a study to reduce steroid use.
Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
Analysis of: FDA Approves Fast Track Designation for Naryx Pharma’s Product for Chronic Sinusitis (www.naryxpharma.com)
I have not found nebulized antibiotic therapy to be of great success in patients with chronic sinusitis.  There are already a few pharmacies that have formulated an array of nebulized antibiotics and I have tried them in a few patients with no success.   
Analysis of: Current Contents: Withdrawal of albuterol inhalers containing CFC propellants (nejm.org)
The FDA's ban on CFC propellants (widely used for asthma and emphysema), which is due to be complete by 2008 has already driven almost all CFC-driven inhalers off the market. The alternative propellant, HFA, is patented by 3M, and only available in branded products which are about 3-5 times as expensive...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Steroid-Free Astelin(R) Nasal Spray (R) Demonstrated Seasonal Allergy Symptom Improvement Within 15 Minutes in Clinical Study (www.drugnewswire.com)
This is one of those studies where the marketing department calls us research and says, "Here's the conclusions to your next study.  Now design and perform a study to reach these results and this conclusion."  Unfortunately, I'm not kidding, and doctors aren't fooled.Years ago, Astelin designed...
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: No Additive Adrenal Suppression Seen With Intranasal Ciclesonide Added to Inhaled Fluticasone (www.medscape.com)
I think the correct way to say it is, "You can eat your cake, and have it too", but no one knows what I'm talking about. This study looked at what happens when you add a nasal steroid (ciclesonide) to someone who is already on Advair 500/50.  Please note that one of the authors has a slight,...
Mitchell Boxer, MD, Assistant Clinical Professor
Albert Einstein College of Medicine
February 27, 2007
Xolair apprehension
Analysis of: FDA Orders Black Box Anaphylaxis Warning for Omalizumab (Xolair) (www.medpagetoday.com)
There is a concern about anaphylaxis secondary to Xolair administration and this may result in longer waiting times after the administration of the drug.
David Engler, MD, Physician
David Engler, MD, Physician
The Allergy Clinic
Analysis of: Controlled-Release Zileuton Tablets Shows Safety Profile Similar to Placebo: Presented at CHEST (www.docguide.com)
Zileuton is much more than just Singulair taken 4 times a day. Its a much better leukotriene antagonist. Its benefit is comparable to inhaled steroids, and, alone, it can improve a patients pulmonary function test results for the volume of air blown out in the first second (FEV1). Singulair and Accolate...

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