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GLG News by Physicians (Germany)

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April 14, 2008
Studies favor new Amgen drug for osteoporosis - will the patients like to inject denosumab?
Analysis of: Amgen Drug Helps Bones | online.wsj.com
Author: GLG Expert Contributor
Postmenopausal osteoporosis is a real problem for a huge number of the older aged patients, and the population is aging. In daily orthopaedic praxis, I see a lot of osteoporosis related fractures of the wrist, the hip, and the vertebral column. Just yesterday, I operated a pseudarthrosis in the femoral...
November 12, 2007
Analysis of CRx-191 in Psoriasis - Comments
Analysis of: CombinatoRx Announces Initiation of Phase 2a Clinical Study of CRx-191 in Psoriasis | www.pipelinereview.com
Author: GLG Expert Contributor
The combination of a topical steroid with an antidepressant seems to be intriguing. Antidepressant have shown some anti-pruritic activity in atopic dermatitis. The major disadvantage of the current investigational drug is the sue with occlussive dressings. That makes it impossible to use the drug for...
November 9, 2007
Bone substitute
Analysis of: Collagen Matrix, Inc. Receives FDA 510(k) Clearance For SynOss(TM) Synthetic Mineral Bone Graft Material | www.medicalnewstoday.com
Author: GLG Expert Contributor
The presented bone substitute is comparable to 240 others in Germany. Only a few bone substitutes differ by bone induction like (DBM(R) Synthes) or (Grafton). Osteoconductive bone substitutes are very common. Only PerOssal(R) by aap, also osteoconductive,  is  selectively  loadable ...
Volker HoffmannOctober 9, 2007
NSF (Nephrogenic Systemic Fibrosis) - Gadoxetic Acid (Primovist)
Analysis of: Study Finds NSF More Common Than Previously Reported | www.dimag.com
Author: Volker Hoffmann, Partner/Owner, Diagnostic Imaging Center
Nephrogenic systemic fibrosis is becoming a severe problem for radiologist and industry as it may prevent physicians from using gadolinium containing contrast agents fearing that they induce nephrogenic systemic fibrosis even in patients without known kidney disease. A stable contrast agent with almost...
September 13, 2007
New drug for superficial bladder cancer with better perspectives as the actual standards? Study design will be the most important aspect to get an approval for EOquin from Spectrum Pharmaceuticals.
Analysis of: Spectrum Pharmaceuticals Initiates Second Registrational Phase 3 Clinical Trial for EOquin(R) in Patients With Non-Invasive Bladder Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
The phase 2 trial data presents results with a better outcome for superficial bladder cancer patients as those treated with standard procedures. A complete remission result after 2 years of 67% is dramatically better then adjuvant Chemoinstillation of immune therapy by BCG. The most important question...
July 25, 2007
Good experience with pcm
Analysis of: Medtronic Neck Disc as Good as Fusion: FDA Staff | www.medscape.com
Author: GLG Expert Contributor
disc prothesis, neck
July 25, 2007
A welcome improvement of the dynamic hip screw
Analysis of: DePuy Launches The Only Technology To Treat Intertrochanteric Hip Fractures Using Traditional Or Minimally Invasive Procedures | www.medicalnewstoday.com
Author: GLG Expert Contributor
Fractures of the upper end of the femur are daily challenge in orthopaedic and trauma surgery in the States, and in Europe. As much as 200000 patients suffer from intretrochanteric fractures, describing a specific site of the upper femur, alone. Thus it is a very relevant challenge in trauma surgery....
July 25, 2007
What do the results presented by SIRTRIS at the 6th Annual Metabolic Diseases Drug Discovery and Development World Summit mean for SIRTRIS?
Analysis of: Sirtris Pharmaceuticals Presents Results of Studies of SIRT1 Activators at 6th Annual Metabolic Diseases Drug Discovery and Development World Summit | www.pipelinereview.com
Author: GLG Expert Contributor
SIRTRIS is one of the leading "sites" worldwide on this field. They have profound knowledge about the human sirtuin gene family.
July 20, 2007
Potential risks of autologous chondrocyte implantation and alternative techniques
Analysis of: Genzyme Announces Positive Results from Carticel® Study at Major Sports Medicine Meeting | www.genzyme.com
Author: GLG Expert Contributor
Articular cartilage injury is a relevant problem in orthopaedic surgery as especially younger people have sports injuries. Articular cartilage injury is followed by a long history of joint problems most probably ending in arthritis of the envolved joint, most often the knee joint. The repair...
July 20, 2007
A good new tool
Analysis of: VAPR® S50 Suction Electrode Offers Optimal Access To Tight Anatomy During Arthroscopic Knee And Shoulder Surgery | www.medicalnewstoday.com
Author: GLG Expert Contributor
Having used the VAPR S90 Radiofrequency Electrode especially in subacromial decompression surgery, that means widening of space in part of the shoulder joint, I feel, the VAPR S50 may be an improvement. Especially in arthroscopic shoulder surgery, the anatomic space is tight. The better the instruments...

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