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GLG News by Pediatricians who Treat RSV (US)

Analysis of: U.S. veterans dept to limit Glaxo's Avandia: report (www.reuters.com)
The United States Veterans Administration is probably the best HMO in the country, provided you are measuring the attainment of good clinical outcomes at reasonable cost.  Believe it or not, the VA, which has the unenviable task of providing healthcare to a relatively sick and historically disenfranchised...
Analysis of: New Allergic Rhinitis Treatment Avamys™ Receives Positive Opinion In Europe (www.medicalnewstoday.com)
From the standpoint of what is clinically practical, Avamys is not a new drug: it is fluticasone in a nasal spray, available for years as Flonase, now off patent and available in the U.S. generically and as Veramyst (the same product as Avamys). Despite claims that Avamys/Veramyst is the first drug...
Analysis of: Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults (www.bio-medicine.org)
Certainly Zingo has the potential to be used in adults, and falls into the category of old, safe drugs with new, clever formulations. But how necessary is this drug in adult practice? It appears to me that there is often confusion between the pain caused by venipuncture and the anxiety and phobia that...
Analysis of: Isis Reports Positive Results of Phase 2 Study of ISIS 301012 in Heterozygous FH Patients (www.pipelinereview.com)
This is a well written article of an impressive study. Despite small sample size, there was a clear dose response that achieved statistical significance witha  VERY robust LDL reduction in paitents already on maximal conventional lipid lowering agents. This paves the way to larger and longer term...
Analysis of: Isis Reports That ISIS 301012 is Well Tolerated in Patients Treated for Five Or More Months (www.pipelinereview.com)
ISIS 301012 is an important agent in the armenentarium to treat an unmet group of patients with refractory hypercholesterolemia or familial hypercholesterolemia. With outcome directly proportional to amount of LDL lowered, it is important to not just control LDL, but also lower it to aceptable...
Analysis of: Maker Seeks to Restrict Cancer Drug Used on Eye (www.nytimes.com)
-Avastin has been repackaged by some compounding pharmacies in place of Lucentis for an indication for which Avastin is not approved.  They are both Genentech drugs, but with Lucentis being much more expensive.  -This is a bit like grinding up amoxicillin tablets, making them into a suspension,...
Analysis of: Boehringer Ingelheim News Page -- 5th Bullet Point (www.boehringer-ingelheim.com)
Flibanserin is, at its root, a molecule with antidepressant activity.  Decreased libido is, at its root, a cardinal symptom of depression.  So the notion that an antidepressant drug might increase the sexual desire in those who have lost it is not so far-fetched, and pre-clinical trials in...
Analysis of: Some babies get too much fluoride (www.mlive.com)
Fluorosis may occur from hidden sources.  It may be reduced by using mineral free water to mix with powdered formula or solely breast feeding.  Fluorosis can cause a permanent staining of the secondary teeth.
Analysis of: Some babies get too much fluoride (www.mlive.com)
Since dental disease remains one of the most common to affect both American children and adults, it is unlikely that the cosmetic issues associated with fluorosis would result in a recommendation against the fluoridation of public water systems.  Fluoridation is a valuable public health measure...
Analysis of: FDA Approves Expanded Label For FluMist(R) To Include Children Two To Five Years Of Age (www.medicalnewstoday.com)
-FluMist indications were just expanded, reducing the minimum age of administration to 2 years old (from 5). -This will make FluMist a desired product (by name) for parents seeking to protect their toddlers and preschoolers from flu but who also desire not to cause pain/crying/suffering. ...

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