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GLG News by Pancreatic Cancer Oncologists in the U.S.

Brian Abbott, MD, Medical Director of Hematology
Brian Abbott, MD, Medical Director of Hematology
Big Sky Oncology
Analysis of: Phase II study of lenalidomide in transfusion-dependent, low- and intermediate-1-risk myelodysplastic syndromes with karyotypes other than deletion 5q (bloodjournal.hematologylibrary.org)
Revlimid benefits are often over-stated in non-5Q minus MDS. The cost is a hurdle for many patients with poor prescription plans. Vidaza and Dacogen seem superior in my experience for higher risk patients.
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Major Phase 3 Trial Shows Zevalin(R) Extends Progression-Free Survival in one of the most common types of Lymphoma (www.pipelinereview.com)
The recent study implies and improved outcome with zevalin The radio immunoconjugates have bee anything but a success story
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
September 20, 2007
Xeloda Suplants 5FU
Analysis of: Phase III Study of Capecitabine Plus Oxaliplatin Compared With Continuous-Infusion Fluorouracil Plus Oxaliplatin As First-Line Therapy in Metastatic Colorectal Cancer: Final Report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial (jco.ascopubs.org)
Xeloda has proven equal to infusional 5FU in recent colorectal cancer trial Xeloda is an oral agent versus iv 5FU and is therefore prefered therapy Xeloda has a diffrenet toxicity profile than infusional 5FU
Taral Patel, MD, Oncologist
Taral Patel, MD, Oncologist
Mid Ohio Oncology Hematology Inc.
August 29, 2007
CMS
Analysis of: New Medicare Regulations Adopted To Reduce Certain Hospital Infections And Medical Errors (www.medicalnewstoday.com)
CMS is doing right thing. This will aviod pt fall and bedsore during hospitalzation
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Poniard Pharmaceuticals Announces Initiation of Picoplatin Phase 2 Trial in First-line Treatment of Hormone-Refractory Prostate Cancer in Combination with Docetaxel and Prednisone (money.cnn.com)
Recent studies demonstrate benefit with picoplatin in HRPCa Other trials have used differnt platinums such as Satraplatin in HRPCa with encouraging results Othe tumors have also benefitted from the newer second/ third generation platinums
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Amgen Responds to Final CMS National Coverage Determination on Use of Erythropoiesis-Stimulating Agents in Oncology (www.pipelinereview.com)
CMS recently tried to glut tohe use of ESAs ESAs have had considerable backing in trial results EsAs situation is just a continuation of the reimbursement disaster being established by CMS with indemity plans to follow
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Phase II Clinical Trial of the Epothilone B Analog, Ixabepilone, in Patients With Non–Small-Cell Lung Cancer Whose Tumors Have Failed First-Line Platinum-Based Chemotherapy (jco.ascopubs.org)
Ixabepilone is the first in a new class of antineoplastic agents.   This international, randomized, phase II trial assessed two administration schedules of ixabepilone as second-line therapy in patients with non–small-cell lung cancer There may be concern for cytotoxics versus biologics in todays...
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Bristol-Myers Squibb and Imclone Systems Significantly Expand ERBITUX Clinical Development Program (www.pipelinereview.com)
Erbitux has promising results in colorectal cancer trials. Erbitux has a  future in colorectal cancer. Erbitux has some pending trilas that could explode the drug's popularity. Erbitux may have an advantage over Avastin .
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
August 9, 2007
VEGF trap
Analysis of: Bayer HealthCare and Regeneron initiate Phase 3 global development program for VEGF Trap-Eye in wet age-related macular degeneration (AMD) (www.pipelinereview.com)
Vegf trap useful in wet MD Vegf trap will be a proft maker for this indication Vegf trap is also a contender in cancer therapy
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Taking statins may increase cancer risk (www.timesonline.co.uk)
Statins have recent reputation as cancer promoting. Statins also have demonstrated benefit in treating cancer patients Statins can be eliminated based on the first issue

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