GLG News by Pain Physicians (US)

The availability of any existing opioid molecule as a sustained-release preparation, eg Vicodin CR, is an advance in pain management.  That being said, however, there is little evidence that the risk of abuse or addiction is less with SR opioids.  In fact, the (usually) higher doses is SR...

ACR16 is part of a class of drugs called dopaminergic stabilizers. These drugs modulate the effect of dopamine (a neurotransmitter secreted naturally by the brain). While more effects and interactions related to dopamine are constantly being discovered, it is known that dopamine plays a role in movement...

Mipomersen (formerly known as ISIS 301012) is a in class of novel therapeutic agents that reduce the production of a protein in the liver that is responsible for cholesterol production. It is though that inhibiting that production on a molecular level would decrease the levels of cholesterol. Mipomersen...

Antibodies are formed by the bodies own immune system to any foreign substances it encounters. Tumors are considered by the body to be foreign at it often requires a genetic mutation for cells to become cancerous. Cancers are able to circumvent these natural antibodies by various means but there is...

Situins are enzymes that regulate predetermined cell death, activity in muscle and fat cells as well as energy expenditure. There are several classes of these enzymes (SIRT 1 through 7). The technology is promising in that it promises to regulate some of the causes of diabetes and obesity rather than...

MicroRNA and their related cousins small interfering RNA, are small molecules that operate in cell regulation. As such they have function in cancer, inflammatory disease, heart and kidney disease.

Copaxone has become the leading treatment for relapsing remitting MS in the US.  The results of the PRECISE trial will likely add to TEVA's sales momentum and boost sales further.

PI 3-kinases are enzymes that play a role in the functioning of cells and their response to stimuli. In essence, these enzymes form portions of the ‘production line’ in cells. Turning up the tempo in this 'production line' is though to play a role in cancer growth and uncontrolled inflammation...

Interleukins (IL's) are a family of mediators that play a part in the inflammatory response. As such they play a role in asthma and other allergic disorders. There are at least 29 interleukins known of which three types are currently being targeted by Medimmune (a division of Astra).

Potassium channels are ‘pores’ in the membrane surrounding cells that modulate the flow of potassium (also called ‘K+’). This modulation is one of the basic interactions of life in all living cells. The scientific community is still learning the ramification of the modulation of these channels.