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GLG News by PPI Prescribers for Heartburn (US)

Analysis of: Gardasil, Merck's Cervical Cancer Vaccine, Demonstrated Efficacy in Preventing HPV-Related Disease in Males in Phase III Study (www.fiercebiotech.com)
This study reveals the nature of the disease- it affects both men and women.   This study confirms the benefit of use of Gardasil in boys and men.   
September 2, 2008
Byetta Saves Lives
Analysis of: FDA Alert: Hemorrhagic or Necrotizing Pancreatitis in Patients Taking Byetta (www.fda.gov)
1.Hypertriglyceridemia causes pancreatitis 2.Most PCP, endocrinologists, and cardiologists are not effectively treating high triglycerides, and may make it worse by recommending a low fat = high carb diet 3.Accord data with 75% reduction in death, and patients desparate for wt loss will continue to...
Analysis of: Heart Stents No Better Than Drugs for Chest Pain Over Time (www.bloomberg.com)
Most hospitals are financially built on their heart programs. The "agressive" medical arm is conservative by our standards yet as good as stents at far less cost. If this was truly pursued by large companies with TPA insurance plans, their overall cost would drop with large savings in healthcare costs....
August 18, 2008
Byetta saves lives
Analysis of: Lilly Diabetes Drug Shows a Life-Extending Promise (www.nytimes.com)
The ACCORD trial results were no suprise to our diabetes practice. We have been heavy users of Byetta since launch in 2005, and have seen the same results in our population of > 2000 diabetics with over 700 on Byetta. Since the Simpson et al study in the Canadian Journal of Medicine (CMAJ 2006;174(2):169-74)...
Dipti Doshi, MD, Rheumatologist
HEALTHCARE PARTNERS MEDICAL GROUP
Analysis of: Trubion Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Rheumatoid Arthritis (www.pipelinereview.com)
Drug therapies for RA include (NSAIDS), DMARDS, and, most recently, biologics. Biologics currently on the market for RA target immune messengers called cytokines, which promote the damaging inflammatory process, and include anti-tumor necrosis factor (TNF) drugs – infliximab , etanercept,adalimumab,...
Analysis of: Efficacy of Botulinum Toxin Does Not Sag Over Time (www.medscape.com)
The long term efficacy of botulinum toxin Type A for the treatment of glabellar frown lines was recently discussed  in San Antonio, Texas at the 66th annual meeting of the American Association of Dermatology. Kawashima and other fellow Japanese investigators presented long-term (64 weeks)...
Analysis of: Hospice Reimbursement for Nursing Home Patients (oig.hhs.gov)
Those programs that have a large census in the nursing home NH will be at risk for decreased revenues and closer scrutiny of their programs. Growth estimates for all programs that center their services on NFs will need to change their focus.
Analysis of: Medtronic Voluntarily Suspends Distribution Of Sprint Fidelis® Defibrillation Leads (www.medicalnewstoday.com)
1) Data only shows trend towards higher lead fracture, not statistically significant on current numbers. 2) Medtronics did the "right thing". No attempts to hide data. 3) Number of potential claims should be minimal, as this is NOT a recall. Rather, more carefull monitoring of the already implanted...
Dipti Doshi, MD, Rheumatologist
HEALTHCARE PARTNERS MEDICAL GROUP
Analysis of: Anesiva Announces Phase 2 Data Showing Substantial, Long-Term Pain Reductions with Adlea(TM) (formerly 4975) in Osteoarthritis of the Knee (www.pipelinereview.com)
Pharmacokinetic studies of Adlea showed that when it is locally administered to the site of pain, there appears to be limited systemic exposure. Its short duration of systemic exposure (hours) relative to the long duration of analgesia (12 weeks) resulting from a single treatment course of Adlea is...
Dipti Doshi, MD, Rheumatologist
HEALTHCARE PARTNERS MEDICAL GROUP
Analysis of: New Data Confirms Significant Improvement of Disease Signs and Symptoms in Patients with Rheumatoid Arthritis (pharmalive.com)
Very important new treatment emerging in field of rheumatoid arthritis along with other drugs in pipeline. IL-6 receptor blocker. New Mechanism of action. Has positive priliminary endpoint results at 24 week study for RA compared to DMARD therapy alone.

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