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GLG News by Oncology Physicians who Treat CID (US)

Analysis of: Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non–Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy (jco.ascopubs.org)
Lung cancer patients who have increased gene copies of EGFR do better with Cetuximab than do those who do not.
Analysis of: Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer (jco.ascopubs.org)
Individualizing chemotherapy depending on histology (adenocarcinomas) shows that Alimta/CisPlatin appears to be more convenient and less toxic than its stablemate Gemzar.
Analysis of: Rituximab and Intravenous Immune Globulin for Desensitization during Renal Transplantation (content.nejm.org)
For patients with antibodies that may make renal transplants problematic, Rituxan may make them possible!
Analysis of: Glaxo Seeks Guidance From Health Systems (online.wsj.com)
GSK is discussing drug development with European countries and not the US. Implications???
Analysis of: Bill to Block Medicare-Fee Cuts (online.wsj.com)
Medicare will not cut physicians fees but will cut payments in HMO driven Medicare "advantage" plans. This means that the republicans will be unable to "feather the nest" of their insurer friends!
Analysis of: Pricey Drugs Put Squeeze on Doctors (online.wsj.com)
Chemotherapy drugs are so costly that not only are the patients unable to pay co-pays, but oncologists are laying out hundreds of thousands of dollars with only a promise they will be reimbursed.
Analysis of: Clash on Preventing Cut to Doctor Payments (online.wsj.com)
11% drop in physician re-imbursement vs HMO sponsored Medicare "advantage" programs. Who will win out?
Analysis of: Costly Cancer Drug Offers Hope, but Also a Dilemma (www.nytimes.com)
Extraordinarily expensive Avastin makes all think twice before using, due to ?? efficacy data as well as questions re: quality of life v survival benefits.
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: One drug, many uses. Good idea? (www.indystar.com)
Lilly has devoted substantial energy/expense in developing Cymbalta for many indications.  Is this at the expense of developing novel agents? 
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: China Muscles In On The Generics Industry (www.pharmalot.com)
Several Chinese companies are set to enter the generic drug market ove the next year.  If these agents are demonstrated to be safe, they could have a large impact on the generic drug industry.

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