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GLG News by Oncology Physicians who Treat CID (US)

Analysis of: Randomized Phase II Trial of a Toll-Like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination With First-Line Taxane Plus Platinum Chemotherapy for Advanced-Stage Non–Small-Cell Lung Cancer (jco.ascopubs.org)
"The investigator-assessed objective response rate (complete and partial response), including both confirmed and unconfirmed responses, was 38% in the PF-3512676 plus chemotherapy arm and 19% in the chemotherapy-alone arm (P = .043)." In other words. IT MAY WORK!
Analysis of: Insurers Expect Health-Care Costs To Rise More Than 10% Next Year (online.wsj.com)
10% increase in medical spending when the overall cost of living is 1/2 of medical costs and we are happy??
Analysis of: UK Says Kidney Cancer Drugs Are Too Pricey (www.pharmalot.com)
Pfizer’s Sutent, Wyeth’s Torisel, Bayer’s Nexavar and Avastin, sold by Roche and Genentech have been deemed too expensive to be paid for by UK agencies
Analysis of: Salmonella Is Tested To Fight Cancer Cells (online.wsj.com)
Salmonella targeting cancer cells? In humans???
Analysis of: Panel Urges End to Prostate Screening at Age 75 (www.nytimes.com)
Since treatment may be worse than the disease it is being recommended that routine prostate cancer screening be stopped after the age of 75.
Analysis of: Amgen Told to Reword Drug Label (www.nytimes.com)
Amgens Aranesp sales fell 26% and J & J's Procrit sales fell 23%."Yaron Werber, a biotechnology analyst at Citi Investment Research, estimated that the new label could reduce the use of Aranesp for cancer patients in this country — the drug is also used by people with kidney disease — by an additional...
Analysis of: Corrections Weaken Cancer Study (online.wsj.com)
Lung cancer screening does not appear to prevent death at least in this study.
Analysis of: Roche Files Avastin for Wider Label in EU (www.therapeuticsdaily.com)
"The filing is supported by data from the phase III Avado trial, which investigated Avastin in combination with docetaxel compared wwith docetaxel alone in the first-line treatment of patients with metastatic breast cancer, Roche said in a statement."
Analysis of: Sorafenib in Advanced Hepatocellular Carcinoma (content.nejm.org)
Sorafenib increases time to progression and median survival in HCC. (World wide a major neoplasm)
Analysis of: Detection of Mutations in EGFR in Circulating Lung-Cancer Cells (content.nejm.org)
Peripheral blood in patients with metastatic non small cell lung cancer (NSCLCA) can determine the presence of EGFR mutations in circulating cancer cells that will reveal sensitivity to TKI's- Erbitux (ImClone & BMS), Tarceva (Genentech) and even Iressa (AZ).

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