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GLG News by Oncologists who Treat Leukemia (US)

Analysis of: Oncophage(R) Approved in Russia for the Treatment of Intermediate-Risk Kidney Cancer (www.pipelinereview.com)
Antigenics Inc. (NASDAQ: AGEN) had to go to Russia to perform this clinical trial???
Analysis of: Studies Find Genetic Link to Smoking (www.nytimes.com)
Gene driven nicotine receptors will predispose to increased smoking. What will this lead to?? Increased addiction due to mutations increases cancer risk.
Analysis of: Pfizer Ends Clinical Trial Of Melanoma Treatment (online.wsj.com)
Drug (monoclonal ab?) failed in a phase III trial vs chemotherapy (not particularly effective.)
Analysis of: Unexpected Toxicity with Panitumumab Plus Chemotherapy-Bevacizumab Combo in Colorectal Cancer (www.oncology-times.com)
Vectibix's undue toxicity without obvious benefits punctures Amgen's hope of finding a first or even second line use for this EGFR directed monoclonal antibody.
Analysis of: OXiGENE Begins Phase II NSCLC Trial of ZYBRESTAT(TM) in Combination with Bevacizumab and Chemotherapy (www.pipelinereview.com)
OXiGENE, Inc's., ZYBRESTAT(TM) (fosbretabulin), a vascular disrupting agent (?) is being given with Taxol/Carboplatin (T/C) in a randomized Phase II study. Soooo T/C with or without ZYBRESTAT.
Analysis of: Cancer risk seen with J&J foot gel: FDA (uk.reuters.com)
 "A Johnson & Johnson foot gel used by diabetics may increase the risk of cancer and death, U.S. health officials said on Thursday in announcing an investigation into the issue."
Analysis of: Oxford BioMedica Report Encouraging New Phase II Trial Results With TroVax(R) in Prostate Cancer (www.pipelinereview.com)
Phase II results ++
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: Immunomedics Develops New Immunoconjugates for Targeted Chemotherapy of Pancreatic and Other Cancers (www.pipelinereview.com)
Immunomedics has developed three new immunoconjugates between monoclonal antibodies and SN-38 i an effort to target colon, pancreas and lung cancer.  Preclinical data are effective in a metastatic colon cancer model but there are no clinical data.
Analysis of: Study Ties Belly Fat to Dementia (online.wsj.com)
"Belly Fat" in middle age can be associated with the development of dementia as one ages.
Analysis of: Cigarette Company Paid for Lung Cancer Study (www.nytimes.com)
Support from a cigarette manufacturer raises questions as to the conclusions from this study which says early detection by repetitive CT's can improve cancer cure rates by early detection. (making smoking safer?)

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