Analysis of:
Erbitux Slightly Boosts Survival in Cancer Study (online.wsj.com)
Basically?? It's a bust until we see subset analysis. It is possible adenocarcinomas as well as non smokers will show better survival
Analysis of:
Hints of Progress in Drugs Treating Brain Cancer (www.nytimes.com)
For the first time in decades, several drugs like Temodar and Avastin and tumor vaccines ( Avant and others) have shown increased overall survival even in adavnaced and recurrent brain tumors as glioblastoma multiforme. Several agents are in the pipeline, and more Big Pharma involvement is expected...
Analysis of:
Phase II trial of gemcitabine, docetaxel, and cetuximab in advanced non-small-cell lung cancer (NSCLC). (www.abstract.asco.org)
The epidermal growth factor antagonist Erbitux did not improve response rates in newly diagnosed patients with advanced non-small cell lung cancer ( NSCLC). Many patients had hypersensitivity reactions to Cetuximab, which has to be content with its role in colon cancer treatment and to some extent...
Analysis of:
Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia (bloodjournal.hematologylibrary.org)
In a clinical trial from MD Anderson, Celgene's oral immunomodulatory agent , Revlimid showed a modest, yet impressive, overall response rate of 32% in patients with refractory, heavily pre-treated CLL. With already proven efficacy in other hematological malignancies, like multiple myeloma, myelofibrosis,...
Analysis of:
Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia (bloodjournal.hematologylibrary.org)
Revlimid has activity in Chronic Lymphatic Leukemia (CLL) in addition to myeloma and myelodysplasia.
Analysis of:
Mixed Outcomes in Laparoscopy for Prostates (www.nytimes.com)
Higher recurrance rate???!!!
Analysis of:
China Muscles In On The Generics Industry (www.pharmalot.com)
The Chinese government funded many manufacturing plants for biologics about 15 years ago, and many are bankrupt because of noninforced patent laws
Analysis of:
Hints of Progress in Drugs Treating Brain Cancer (www.nytimes.com)
While no slam dunk cures are noted, drugs such as Avastin (Genentech), Temodar (Schering-Plough) & Avant/Pfizer vaccines are making an impact on "Brain Cancer" survival.
Analysis of:
Proteolix Initiates Phase 2 Clinical Trial of Carfilzomib in Patients with Relapsed Solid Tumors (www.pipelinereview.com)
Proteolix's selective proteosome inhibitor PR-171 have shown pre-clinical activity in slid tumor animal models, but only a small Phase Ib clinical trial of 14 patients have been completed. based on spectrum of activity of a similar compound ( Valcade, Mellinium), the main efficacy of this agent...
Analysis of:
Phase II trial of gemcitabine, docetaxel, and cetuximab in advanced non-small-cell lung cancer (NSCLC). (www.abstract.asco.org)
" Conclusions: Cetuximab does not appear to add to treatment efficacy when combined with gemcitabine and docetaxel in advanced NSCLC. A high rate of severe cetuximab HSRs necessitated trial closure at our Nashville site." Not very promising.