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GLG News by Oncologists Specializing in Hematologic Malignancies in the U.S.

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August 29, 2008
Amgen Rewords Label: Less Use of Procrit
Analysis of: Amgen Told to Reword Drug Label | www.nytimes.com
Author: Michael Grossbard, Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons
The FDA required Amgen to revise the label for Procrit and Aranesp so that these agents are not used until a patient's hemoglobin drops below 10 or in the setting of potentially curative therapy.
August 29, 2008
Transparency in Healthcare: How to Assess?
Analysis of: Transparency in Healthcare | www.hospitalimpact.org
Author: Michael Grossbard, Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons
The author argues that transparency in healthcare will be an important step forward for the consumer.
August 29, 2008
Avastin: Worth the Cost?
Analysis of: Costly Cancer Drug Offers Hope, but Also a Dilemma | www.nytimes.com
Author: Michael Grossbard, Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons
Avastin improves survival in colon cancer and lung cancer and improves progression free survival in breast cancer- clinically meaningful outcomes.  Yet these gains are of relatively short duration and the cost of Avastin is significant- 50,000 to 100,000 dollars per year.
August 28, 2008
NICE States Novel Therapies for Renal Cell Cancer Too Costly
Analysis of: UK Says Kidney Cancer Drugs Are Too Pricey | www.pharmalot.com
Author: Michael Grossbard, Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons
NICE has stated that the cost of several novel agents for the treatment of renal cell cancer including Sutent, Torisel, Avastin, and Nexavar exceeds the benefit when assessed by quality adjusted life years (QALY) gained from the therapies.
July 30, 2008
Avastin may not get approval of "cost-conscious" EMEA
Analysis of: Roche Files Avastin for Wider Label in EU | www.therapeuticsdaily.com
Author: GLG Expert Contributor
Avastin ( Roche/Genentech) extended time to progression when combined with Docotaxel ( Sanofi-Aventis) in patients with metastatic breast cancer as compared to Docotaxel alone, but did not prolong survival. Unlike approval by the FDA,the EMEA is more cost conscious and may be reluctant to...
July 28, 2008
Doctors and cancer medications: the pressure should be shifted to health plans
Analysis of: Pricey Drugs Put Squeeze on Doctors | online.wsj.com
Author: GLG Expert Contributor
Doctors can not remain in the middle between pharmaceutical companies and insurance and health plans. Reimbursement for oreal and IV drugs should be comparable , in order to avoid over-prescription of IV drugs , even if they are not as efficacious or more toxic. The patient's helath plan ( the government...
July 28, 2008
Lilly is replacing oine of its compounds with another in a subset of NSCLC
Analysis of: Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer | jco.ascopubs.org
Author: GLG Expert Contributor
Pemetrexed (lilly) with Cisplatinum is less toxic and may be more efficacious in a subset of patients with advanced NSCLC than Gemcitibine ( another Lilly compound) /Cisplatin combination. he real question is how this comapres to Avastin ( Genentech) or even the antibody Cetuximab ( Imclone) in...
July 28, 2008
OLD news, but positive results and higher visibility will definitely benefit Bayer
Analysis of: Sorafenib in Advanced Hepatocellular Carcinoma | content.nejm.org
Author: GLG Expert Contributor
The New England Journal of Medicine report confirms that Bayer/Onyx Nexavar prolongs median survival and time to progression in patients with advanced HCC. This trumor is a world wide health problem, so such positive news, although old, in a reputable journal, will lead to wider use of this oral...
July 28, 2008
Erbitux may add to chemotherapy in a subset of NSCLC patients
Analysis of: Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non–Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy | jco.ascopubs.org
Author: GLG Expert Contributor
In a US multicenter Phase II study, Erbitux ( Imclone) added to efficacy of Carboplatinum and Palcitaxel in a subset of NSCLC patients whose tumors had extra copies of EGFR that is targeted by Cetuxiamb. FISH techniques still has problems with standardization and larger number of patients are needed...
July 7, 2008
One Drug Many Uses: Prove It
Analysis of: One drug, many uses. Good idea? | www.indystar.com
Author: Michael Grossbard, Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons
Lilly has devoted substantial energy/expense in developing Cymbalta for many indications.  Is this at the expense of developing novel agents? 

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