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GLG News by Oncologists (US)

Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: China Muscles In On The Generics Industry (www.pharmalot.com)
Several Chinese companies are set to enter the generic drug market ove the next year.  If these agents are demonstrated to be safe, they could have a large impact on the generic drug industry.
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: Roche decision denies cancer drug to Britons (www.ft.com)
Roche has elected not to provide information on the cost effectiveness and clinical effectiveness of Avastin in breast cancer to the medicine advisory board of the British government.  As such, the drug will not be able for first line treatment of these diseases in Britain.
Analysis of: Detection of Mutations in EGFR in Circulating Lung-Cancer Cells (content.nejm.org)
We may be able to analyze EGFR mutations from periperal blood of lung cancer patients. Very frequently enough tissue fromm needle biopsies are not available for analysis. This may replace the need for new biopsies.
Analysis of: Motesanib Diphosphate in Progressive Differentiated Thyroid Cancer (content.nejm.org)
This oral Vascular Endothelial Growth Factor (VEGF) inhibitor appears to have activity in radioresistant differentiated thyroid carcinoma.
Analysis of: One drug, many uses. Good idea? (www.indystar.com)
The public benefits when new uses are found for old drugs.  The benefit comes more quickly as the pharma company does not need to go through as many early studies to allow the approval for the drug use. However, I believe that pharma realizes that new uses for old drugs is not the way...
Analysis of: Efficacy and Safety of Lapatinib As First-Line Therapy for ErbB2-Amplified Locally Advanced or Metastatic Breast Cancer (jco.ascopubs.org)
In a recent JCO article, Laptanib showed clinical efficacy and acceptable safety in a non-randomized trial involving newly diagnosed patients with advanced oe metastatic breast cancer. Larger trials are needed to confirm efficacy and explore if it is more potent than Genentech's Herceptin. For now,...
Analysis of: Roche decision denies cancer drug to Britons (www.ft.com)
Avastin's recent FDA approval for m-breast cancer ( m-BCA) was lukewarm at best with no overall survival benefit yet and modest PFS data. European regulatory agencies usually require cost efficacy data and more strict data, which are not readily available for Roche/Genetech. The British market is not...
Analysis of: Roche decision denies cancer drug to Britons (www.ft.com)
Patients who wish to receive Avastin for breast and lung Cancer will need to pay for it themselves.
Analysis of: Medicare fees to doctors fall Tuesday (news.yahoo.com)
Rising costs for care of seniors in physician offices will be made more painful by the reimbursement cuts. Will it impede care of seniors??
Analysis of: Europe Backs Anemia-Drug Warnings (online.wsj.com)
Due to possible tumor growth warnings will be attached to the use of erythropoietin agents.

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